@article{b8239c0c50e94db6a98079366255674e,
title = "Ventricular arrhythmia in heart failure patients with reduced ejection fraction and central sleep apnoea",
abstract = "Cheyne-Stokes respiration (CSR) may trigger ventricular arrhythmia in patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnoea (CSA). This study determined the prevalence and predictors of a high nocturnal ventricular arrhythmia burden in patients with HFrEF and CSA (with and without CSR) and to evaluate the temporal association between CSR and the ventricular arrhythmia burden.This cross-sectional ancillary analysis included 239 participants from the SERVE-HF major sub-study who had HFrEF and CSA, and nocturnal ECG from polysomnography. CSR was stratified in >= 20% and 30 premature ventricular complexes (PVCs) per hour of TRT. A sub-analysis was performed to evaluate the temporal association between CSR and ventricular arrhythmias in sleep stage N2.High ventricular arrhythmia burden was observed in 44% of patients. In multivariate logistic regression analysis, male sex, lower systolic blood pressure, non-use of antiarrhythmic medication and CSR.20% were significantly associated with PVCs >30.h(-1) (OR 5.49, 95% CI 1.51-19.91, p=0.010; OR 0.98, 95% CI 0.97-1.00, p=0.017; OR 5.02, 95% CI 1.51- 19.91, p=0.001; and OR 2.22, 95% CI 1.22-4.05, p=0.009; respectively). PVCs occurred more frequently during sleep phases with versus without CSR (median (interquartile range): 64.6 (24.8-145.7) versus 34.6 (4.8-75.2).h(-1) N2 sleep; p=0.006).Further mechanistic studies and arrhythmia analysis of major randomised trials evaluating the effect of treating CSR on ventricular arrhythmia burden and arrhythmia-related outcomes are warranted to understand how these data match with the results of the parent SERVE-HF study.",
keywords = "ADAPTIVE SERVO-VENTILATION, CHEYNE-STOKES RESPIRATION, NOCTURNAL ARRHYTHMIAS, MORTALITY, ECTOPY, DEATH, RISK, HF, DYSFUNCTION, PREVALENCE",
author = "Christoph Fisser and Jannis Bureck and Lara Gall and Victoria Vaas and Jorg Priefert and Sabine Fredersdorf and Florian Zeman and Dominik Linz and Holger Wohrle and Renaud Tamisier and Helmut Teschler and Cowie, {Martin R.} and Michael Arzt",
note = "Funding Information: Support statement: The SERVE-HF study was supported by ResMed and by grants from the National Institute for Health Research (NIHR) Cardiovascular and Respiratory Biomedical Research Units (MRC). Representatives and scientists from the ResMed participated in the study including design, data collation, data analysis and critical review of the paper. This ancillary analysis was supported by ResMed (M. Arzt) and by a grant from the German Heart Foundation/German Foundation of Heart Research (F/15/20; C. Fisser). Funding information for this article has been deposited with the Crossref Funder Registry. Funding Information: Conflict of interest: C. Fisser reports grants from the German Heart Foundation/German Foundation of Heart Research during the conduct of the study. J. Bureck has nothing to disclose. L. Gall has nothing to disclose. V. Vaas reports grants from the German Society of Sleep Medicine outside the submitted work. J. Priefert has nothing to disclose. S. Fredersdorf has nothing to disclose. F. Zeman has nothing to disclose. D. Linz reports personal fees from Bayer, LivaNova, ResMed and Respicardia outside the submitted work. H. W{\"o}hrle is a former employee of ResMed. R. Tamisier reports grants from ResMed and personal fees from Agiradom, outside the submitted work. H. Teschler reports grants and personal fees from ResMed outside the submitted work. M.R. Cowie reports grants and personal fees from ResMed, personal fees from Respicardia, and grants from Bayer, outside the submitted work. M. Arzt reports grants from ResMed during the conduct of the study; and personal fees from ResMed, grants and personal fees from Philips Respironics, personal fees from Boehringer Ingelheim, NRI, Novartis, JAZZ Pharmaceuticals, Inspire and Bresotec, and grants from the Else-Kroehner Fresenius Foundation, outside the submitted work. Publisher Copyright: {\textcopyright} The authors 2021.",
year = "2021",
month = jul,
day = "1",
doi = "10.1183/23120541.00147-2021",
language = "English",
volume = "7",
journal = "ERJ Open Research",
issn = "2312-0541",
publisher = "European Respiratory Society",
number = "3",
}