Ventilator-associated pneumonia rates after introducing selective digestive tract decontamination

Ronny M. Schnabel*, Johannes B. J. Scholte, Kim E. H. M. Van der Velden, Paul M. H. J. Roekaerts, Dennis C. J. J. Bergmans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The incidence of ventilator-associated pneumonia (VAP) before and after the introduction of selective oral decontamination (SOD) only and selective digestive tract decontamination (SDD) in a general intensive care population was examined. SOD as standard of care was introduced in December 2010 and SDD, including SOD, in January 2012 for all patients with an expected length of intensive care unit (ICU) stay of at least 48 h. The diagnosis of VAP was based on clinical criteria and quantitative cultures of bronchoalveolar lavage fluid. A total of 4945 mechanically ventilated patients accounting for 37 554 ventilator days in the period from 2005 to 2013 were analyzed. The incidence of VAP per 1000 ventilator days declined significantly from 4.38 +/- 1.64 before to 1.64 +/- 0.43 after introduction of SOD/SDD (p = 0.007). Implementation of SOD/SDD as standard of care in ICUs may thus be effective in preventing VAP.
Original languageEnglish
Pages (from-to)650-653
JournalInfectious Diseases
Issue number9
Publication statusPublished - Sept 2015


  • Bronchoalveolar lavage
  • critical care
  • decontamination
  • preventive measures
  • antibacterial agents


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