Abstract

PURPOSE: To investigate whether higher blood pressure and greater arterial stiffness are associated with the presence of macular cysts and whether this association is already present in the absence of micro-aneurysms in individuals with and without type 2 diabetes.

METHODS: Using spectral domain optical coherence tomography (OCT), we performed a macular volume scan in 2647 individuals (mean age 60 ± 8 years, 50% men, 27% type 2 diabetes). The association between macular cysts and 24-hour systolic and diastolic blood pressure, pulse pressure, mean arterial blood pressure, carotid-femoral pulse wave velocity and carotid distensibility was assessed by use of logistic regression.

RESULTS: Twenty-four hours systolic blood pressure was associated with the presence of macular cysts [OR = 1.03 (95% CI 1.00-1.05) per 1 mmHg, p = 0.03]. 24 hr pulse pressure [OR = 1.61 (95% CI 1.11-2.34) per 10 mmHg, p = 0.01] and carotid-femoral pulse wave velocity [OR = 1.16 (95% CI 1.02-1.32) per 1 m/s, p = 0.02] were associated with macular cysts, while carotid distensibility was not [OR = 1.03 (95% CI 0.96-1.11) per 1.0*10-3 /kPa, p = 0.45]. Associations were similar in individuals with and without type 2 diabetes and were already present in the absence of micro-aneurysms.

CONCLUSION: Twenty-four hours systolic blood pressure, 24 hr pulse pressure and carotid-femoral pulse wave velocity are associated with the presence of OCT-detected macular cysts in individuals with and without type 2 diabetes, even in the absence of micro-aneurysms. Therefore, blood pressure and aortic stiffness are potential factors contributing to macular cysts.

Original languageEnglish
Pages (from-to)e860-e868
Number of pages9
JournalActa Ophthalmologica
Volume99
Issue number6
Early online date30 Nov 2020
DOIs
Publication statusPublished - Sep 2021

Keywords

  • macular cysts
  • optical coherence tomography
  • type 2 diabetes
  • vascular risk factors
  • EXPERT CONSENSUS DOCUMENT
  • INTIMA-MEDIA THICKNESS
  • BLOOD-RETINAL BARRIER
  • ARTERIAL STIFFNESS
  • DIABETIC-RETINOPATHY
  • AORTIC STIFFNESS
  • PULSE PRESSURE
  • CAROTID-ARTERY
  • EDEMA
  • EPIDEMIOLOGY

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