VASCULAR ELASTOGRAPHY: A VALIDATION STUDY

Richard G. P. Lopata; Mathijs F. J. Peters; Jan Nijs; Cees W. J. Oomens; Marcel C. M. Rutten; Frans N. van de Vosse

doi:10.1016/j.ultrasmedbio.2014.02.029

VASCULAR ELASTOGRAPHY: A VALIDATION STUDY

Richard G. P. Lopata^*, Mathijs F. J. Peters, Jan Nijs, Cees W. J. Oomens, Marcel C. M. Rutten, Frans N. van de Vosse

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Web of Science)

Abstract

Vascular elastography techniques are promising tools for mechanical characterization of diseased arteries. These techniques are usually validated with simulations or phantoms or by comparing results with histology or other imaging modalities. In the study described here, vascular elastography was applied to porcine aortas in vitro during inflation testing (n = 10) and results were compared with those of standard bi-axial tensile testing, a technique that directly measures the force applied to the tissue. A neo-Hookean model was fit to the stress-strain data, valid for large deformations. Results indicated good correspondence between the two techniques, with GUS = 110 ? 11 kPa and GTT = 108 ? 10 kPa for ultrasound and tensile testing, respectively. Bland-Altman analysis revealed little bias (GUS-GTT = 2 ? 20 kPa). The next step will be the application of a non-linear material model that is also adaptable for in vivo measurements. World Federation for Ultrasound in Medicine & Biology.

Original language	English
Pages (from-to)	1882-1895
Journal	Ultrasound in Medicine and Biology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2014.02.029
Publication status	Published - Aug 2014

Keywords

Ultrasound
Aorta
Elastography
Bi-axial tensile test
Mechanical characterization

Access to Document

10.1016/j.ultrasmedbio.2014.02.029

Cite this

@article{35084f1b2d314d7c83b55fcd9a155615,

title = "VASCULAR ELASTOGRAPHY: A VALIDATION STUDY",

abstract = "Vascular elastography techniques are promising tools for mechanical characterization of diseased arteries. These techniques are usually validated with simulations or phantoms or by comparing results with histology or other imaging modalities. In the study described here, vascular elastography was applied to porcine aortas in vitro during inflation testing (n = 10) and results were compared with those of standard bi-axial tensile testing, a technique that directly measures the force applied to the tissue. A neo-Hookean model was fit to the stress-strain data, valid for large deformations. Results indicated good correspondence between the two techniques, with GUS = 110 ? 11 kPa and GTT = 108 ? 10 kPa for ultrasound and tensile testing, respectively. Bland-Altman analysis revealed little bias (GUS-GTT = 2 ? 20 kPa). The next step will be the application of a non-linear material model that is also adaptable for in vivo measurements. World Federation for Ultrasound in Medicine & Biology.",

keywords = "Ultrasound, Aorta, Elastography, Bi-axial tensile test, Mechanical characterization",

author = "Lopata, {Richard G. P.} and Peters, {Mathijs F. J.} and Jan Nijs and Oomens, {Cees W. J.} and Rutten, {Marcel C. M.} and {van de Vosse}, {Frans N.}",

year = "2014",

month = aug,

doi = "10.1016/j.ultrasmedbio.2014.02.029",

language = "English",

volume = "40",

pages = "1882--1895",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

publisher = "Elsevier Science",

number = "8",

}

TY - JOUR

T1 - VASCULAR ELASTOGRAPHY: A VALIDATION STUDY

AU - Lopata, Richard G. P.

AU - Peters, Mathijs F. J.

AU - Nijs, Jan

AU - Oomens, Cees W. J.

AU - Rutten, Marcel C. M.

AU - van de Vosse, Frans N.

PY - 2014/8

Y1 - 2014/8

N2 - Vascular elastography techniques are promising tools for mechanical characterization of diseased arteries. These techniques are usually validated with simulations or phantoms or by comparing results with histology or other imaging modalities. In the study described here, vascular elastography was applied to porcine aortas in vitro during inflation testing (n = 10) and results were compared with those of standard bi-axial tensile testing, a technique that directly measures the force applied to the tissue. A neo-Hookean model was fit to the stress-strain data, valid for large deformations. Results indicated good correspondence between the two techniques, with GUS = 110 ? 11 kPa and GTT = 108 ? 10 kPa for ultrasound and tensile testing, respectively. Bland-Altman analysis revealed little bias (GUS-GTT = 2 ? 20 kPa). The next step will be the application of a non-linear material model that is also adaptable for in vivo measurements. World Federation for Ultrasound in Medicine & Biology.

AB - Vascular elastography techniques are promising tools for mechanical characterization of diseased arteries. These techniques are usually validated with simulations or phantoms or by comparing results with histology or other imaging modalities. In the study described here, vascular elastography was applied to porcine aortas in vitro during inflation testing (n = 10) and results were compared with those of standard bi-axial tensile testing, a technique that directly measures the force applied to the tissue. A neo-Hookean model was fit to the stress-strain data, valid for large deformations. Results indicated good correspondence between the two techniques, with GUS = 110 ? 11 kPa and GTT = 108 ? 10 kPa for ultrasound and tensile testing, respectively. Bland-Altman analysis revealed little bias (GUS-GTT = 2 ? 20 kPa). The next step will be the application of a non-linear material model that is also adaptable for in vivo measurements. World Federation for Ultrasound in Medicine & Biology.

KW - Ultrasound

KW - Aorta

KW - Elastography

KW - Bi-axial tensile test

KW - Mechanical characterization

U2 - 10.1016/j.ultrasmedbio.2014.02.029

DO - 10.1016/j.ultrasmedbio.2014.02.029

M3 - Article

C2 - 24798385

VL - 40

SP - 1882

EP - 1895

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 8

ER -