Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms

T. T. van Sloten

doi:10.1016/j.artres.2017.05.002

Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms

T. T. van Sloten^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and endothelium (endothelial dysfunction). We have investigated, in a series of epidemiological studies, the role of vascular dysfunction in the pathogenesis of cardiovascular disease, dementia and depression. Data were used of The Hoorn Study, The AGES-Reykjavik Study, The Maastricht Study and The SUVIMAX2 Study. In addition, we did two systematic reviews and an individual participant data meta-analysis. (C) 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	18-23
Number of pages	6
Journal	Artery Research
Volume	19
DOIs	https://doi.org/10.1016/j.artres.2017.05.002
Publication status	Published - Sept 2017

Keywords

Arterial stiffness
Endothelial dysfunction
Cerebral small vessel disease
Dementia
Depression
SMALL VESSEL DISEASE
GENERAL ELDERLY POPULATION
ARTERIAL STIFFNESS
ENDOTHELIAL DYSFUNCTION
MICROVASCULAR FUNCTION
MAJOR SHAREHOLDERS
DIABETES-MELLITUS
AGES-REYKJAVIK
PART I
RISK

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@article{43363c0793e04811953e5a11a216281a,

title = "Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms",

abstract = "Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and endothelium (endothelial dysfunction). We have investigated, in a series of epidemiological studies, the role of vascular dysfunction in the pathogenesis of cardiovascular disease, dementia and depression. Data were used of The Hoorn Study, The AGES-Reykjavik Study, The Maastricht Study and The SUVIMAX2 Study. In addition, we did two systematic reviews and an individual participant data meta-analysis. (C) 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.",

keywords = "Arterial stiffness, Endothelial dysfunction, Cerebral small vessel disease, Dementia, Depression, SMALL VESSEL DISEASE, GENERAL ELDERLY POPULATION, ARTERIAL STIFFNESS, ENDOTHELIAL DYSFUNCTION, MICROVASCULAR FUNCTION, MAJOR SHAREHOLDERS, DIABETES-MELLITUS, AGES-REYKJAVIK, PART I, RISK",

author = "{van Sloten}, {T. T.}",

year = "2017",

month = sep,

doi = "10.1016/j.artres.2017.05.002",

language = "English",

volume = "19",

pages = "18--23",

journal = "Artery Research",

issn = "1872-9312",

publisher = "Elsevier Science",

}

TY - JOUR

T1 - Vascular dysfunction

T2 - At the heart of cardiovascular disease, cognitive impairment and depressive symptoms

AU - van Sloten, T. T.

PY - 2017/9

Y1 - 2017/9

N2 - Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and endothelium (endothelial dysfunction). We have investigated, in a series of epidemiological studies, the role of vascular dysfunction in the pathogenesis of cardiovascular disease, dementia and depression. Data were used of The Hoorn Study, The AGES-Reykjavik Study, The Maastricht Study and The SUVIMAX2 Study. In addition, we did two systematic reviews and an individual participant data meta-analysis. (C) 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.

AB - Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and endothelium (endothelial dysfunction). We have investigated, in a series of epidemiological studies, the role of vascular dysfunction in the pathogenesis of cardiovascular disease, dementia and depression. Data were used of The Hoorn Study, The AGES-Reykjavik Study, The Maastricht Study and The SUVIMAX2 Study. In addition, we did two systematic reviews and an individual participant data meta-analysis. (C) 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.

KW - Arterial stiffness

KW - Endothelial dysfunction

KW - Cerebral small vessel disease

KW - Dementia

KW - Depression

KW - SMALL VESSEL DISEASE

KW - GENERAL ELDERLY POPULATION

KW - ARTERIAL STIFFNESS

KW - ENDOTHELIAL DYSFUNCTION

KW - MICROVASCULAR FUNCTION

KW - MAJOR SHAREHOLDERS

KW - DIABETES-MELLITUS

KW - AGES-REYKJAVIK

KW - PART I

KW - RISK

U2 - 10.1016/j.artres.2017.05.002

DO - 10.1016/j.artres.2017.05.002

M3 - (Systematic) Review article

SN - 1872-9312

VL - 19

SP - 18

EP - 23

JO - Artery Research

JF - Artery Research

ER -

Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms

Abstract

Keywords

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