Vascular dysfunction : at the heart of cardiovascular disease, cognitive impairment and depressive symptoms

Research output: ThesisDoctoral ThesisInternal

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This dissertation focussed on the damaging effects of deterioration of vascular function on the body. It is shown that deterioration of function of large blood vessels (due to vascular stiffening), small blood vessels (microvascular dysfunction) and the lining of blood vessels (endothelial dysfunction) not only plays an important role in the development of cardiovascular disease, but also in the development of dementia and depression. Vascular dysfunction is therefore an important new lead for preventing and treating cardiovascular disease, dementia and depression. Various studies were used, including the Maastricht Study, the Hoorn Study, the AGES-Reykjavik Study and the Rotterdam Study.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Stehouwer, Coen, Supervisor
  • Henry, Ronald, Co-Supervisor
  • Schram, Miranda, Co-Supervisor
Award date20 May 2015
Place of PublicationMaastricht
Print ISBNs9789462596375
Publication statusPublished - 2015


  • blood vessels
  • vascular dysfunction
  • cardiovascular disease
  • dementia
  • depression

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