Variability of Sleep Apnea Severity and Risk of Atrial Fibrillation

Dominik Linz; Anthony G. Brooks; Adrian D. Elliott; Chrishan J. Nalliah; Jeroen M. L. Hendriks; Melissa E. Middeldorp; Celine Gallagher; Rajiv Mahajan; Jonathan M. Kalman; R. Doug McEvoy; Dennis H. Lau; Prashanthan Sanders

doi:10.1016/j.jacep.2019.03.005

Variability of Sleep Apnea Severity and Risk of Atrial Fibrillation

Dominik Linz
, Anthony G. Brooks
, Adrian D. Elliott
, Chrishan J. Nalliah
, Jeroen M. L. Hendriks
, Melissa E. Middeldorp
, Celine Gallagher
, Rajiv Mahajan
, Jonathan M. Kalman
, R. Doug McEvoy
, Dennis H. Lau
, Prashanthan Sanders^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

ObjectivesThis study sought to determine night-to-night variability in the severity of sleep-disordered breathing (SDB) and the dynamic intraindividual relationship to daily risk of incident atrial fibrillation (AF) by using simultaneous long-term day-by-day SDB and AF monitoring.BackgroundNight-to-night variability in SDB severity may result in a dynamic exposure to SDB related conditions impacting the timing and extent of cardiovascular responses.MethodsThis study was an observational cohort study. Daily data for AF burden and average respiratory disturbance index (RDI) were extracted from pacemakers capable of monitoring nightly SDB and daily AF burden in 72 patients. Nightly RDI values were grouped into quartiles of severity within each patient. AF burdens of >5 min, >1 h, and >12 h were the outcome variables.ResultsA total of 32% of patients had a mean RDI of ≥20/h, indicative of overall severe SDB. There was significant night-to-night variation in RDI reflected by an absolute SD of ±6.3 events/h (range 2 to 14 events/h) within any given patient. Within each patient, the nights with the highest RDI (in their highest quartile) conferred a 1.7-fold (1.2 to 2.2; p

Original language	English
Pages (from-to)	692-701
Number of pages	10
Journal	JACC: Clinical Electrophysiology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/j.jacep.2019.03.005
Publication status	Published - 2019
Externally published	Yes

Keywords

atrial fibrillation burden dynamic substrate night-to-night variability pacemaker sleep-disordered breathing

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10.1016/j.jacep.2019.03.005

Cite this

@article{ccfffe070dd34edc8efc192830228244,

title = "Variability of Sleep Apnea Severity and Risk of Atrial Fibrillation",

abstract = "ObjectivesThis study sought to determine night-to-night variability in the severity of sleep-disordered breathing (SDB) and the dynamic intraindividual relationship to daily risk of incident atrial fibrillation (AF) by using simultaneous long-term day-by-day SDB and AF monitoring.BackgroundNight-to-night variability in SDB severity may result in a dynamic exposure to SDB related conditions impacting the timing and extent of cardiovascular responses.MethodsThis study was an observational cohort study. Daily data for AF burden and average respiratory disturbance index (RDI) were extracted from pacemakers capable of monitoring nightly SDB and daily AF burden in 72 patients. Nightly RDI values were grouped into quartiles of severity within each patient. AF burdens of >5 min, >1 h, and >12 h were the outcome variables.ResultsA total of 32\% of patients had a mean RDI of ≥20/h, indicative of overall severe SDB. There was significant night-to-night variation in RDI reflected by an absolute SD of ±6.3 events/h (range 2 to 14 events/h) within any given patient. Within each patient, the nights with the highest RDI (in their highest quartile) conferred a 1.7-fold (1.2 to 2.2; p ",

keywords = "atrial fibrillation burden dynamic substrate night-to-night variability pacemaker sleep-disordered breathing",

author = "Dominik Linz and Brooks, \{Anthony G.\} and Elliott, \{Adrian D.\} and Nalliah, \{Chrishan J.\} and Hendriks, \{Jeroen M. L.\} and Middeldorp, \{Melissa E.\} and Celine Gallagher and Rajiv Mahajan and Kalman, \{Jonathan M.\} and McEvoy, \{R. Doug\} and Lau, \{Dennis H.\} and Prashanthan Sanders",

note = "10.1016/j.jacep.2019.03.005",

year = "2019",

doi = "10.1016/j.jacep.2019.03.005",

language = "English",

volume = "5",

pages = "692--701",

journal = "JACC: Clinical Electrophysiology",

issn = "2405-500X",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Variability of Sleep Apnea Severity and Risk of Atrial Fibrillation

AU - Linz, Dominik

AU - Brooks, Anthony G.

AU - Elliott, Adrian D.

AU - Nalliah, Chrishan J.

AU - Hendriks, Jeroen M. L.

AU - Middeldorp, Melissa E.

AU - Gallagher, Celine

AU - Mahajan, Rajiv

AU - Kalman, Jonathan M.

AU - McEvoy, R. Doug

AU - Lau, Dennis H.

AU - Sanders, Prashanthan

N1 - 10.1016/j.jacep.2019.03.005

PY - 2019

Y1 - 2019

N2 - ObjectivesThis study sought to determine night-to-night variability in the severity of sleep-disordered breathing (SDB) and the dynamic intraindividual relationship to daily risk of incident atrial fibrillation (AF) by using simultaneous long-term day-by-day SDB and AF monitoring.BackgroundNight-to-night variability in SDB severity may result in a dynamic exposure to SDB related conditions impacting the timing and extent of cardiovascular responses.MethodsThis study was an observational cohort study. Daily data for AF burden and average respiratory disturbance index (RDI) were extracted from pacemakers capable of monitoring nightly SDB and daily AF burden in 72 patients. Nightly RDI values were grouped into quartiles of severity within each patient. AF burdens of >5 min, >1 h, and >12 h were the outcome variables.ResultsA total of 32% of patients had a mean RDI of ≥20/h, indicative of overall severe SDB. There was significant night-to-night variation in RDI reflected by an absolute SD of ±6.3 events/h (range 2 to 14 events/h) within any given patient. Within each patient, the nights with the highest RDI (in their highest quartile) conferred a 1.7-fold (1.2 to 2.2; p

AB - ObjectivesThis study sought to determine night-to-night variability in the severity of sleep-disordered breathing (SDB) and the dynamic intraindividual relationship to daily risk of incident atrial fibrillation (AF) by using simultaneous long-term day-by-day SDB and AF monitoring.BackgroundNight-to-night variability in SDB severity may result in a dynamic exposure to SDB related conditions impacting the timing and extent of cardiovascular responses.MethodsThis study was an observational cohort study. Daily data for AF burden and average respiratory disturbance index (RDI) were extracted from pacemakers capable of monitoring nightly SDB and daily AF burden in 72 patients. Nightly RDI values were grouped into quartiles of severity within each patient. AF burdens of >5 min, >1 h, and >12 h were the outcome variables.ResultsA total of 32% of patients had a mean RDI of ≥20/h, indicative of overall severe SDB. There was significant night-to-night variation in RDI reflected by an absolute SD of ±6.3 events/h (range 2 to 14 events/h) within any given patient. Within each patient, the nights with the highest RDI (in their highest quartile) conferred a 1.7-fold (1.2 to 2.2; p

KW - atrial fibrillation burden dynamic substrate night-to-night variability pacemaker sleep-disordered breathing

U2 - 10.1016/j.jacep.2019.03.005

DO - 10.1016/j.jacep.2019.03.005

M3 - Article

SN - 2405-500X

VL - 5

SP - 692

EP - 701

JO - JACC: Clinical Electrophysiology

JF - JACC: Clinical Electrophysiology

IS - 6

ER -

Variability of Sleep Apnea Severity and Risk of Atrial Fibrillation

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Keywords

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