Value of gadofosveset-enhanced MRI and multiplanar reformatting for selecting good responders after chemoradiation for rectal cancer

Luc A. Heijnen, Monique Maas, Max J. Lahaye, Ulrich Lalji, Doenja M. J. Lambregts, Milou H. Martens, Robert G. Riedl, Geerard L. Beets, Regina G. H. Beets-Tan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVES: Our primary objective was to evaluate diagnostic performance of gadofosveset T1-weighted magnetic resonance imaging (T1W MRI) for discriminating between ypT0-2 and ypT3-4 tumours after chemoradiation therapy (CRT) for rectal cancer compared with T2W MRI for a general and expert reader. Second objectives included assessing the value of multiplanar reformatting (MPR) and interobserver agreement. METHODS: A general and expert reader evaluated 49 patients for likelihood of ypT0-2 tumour after CRT on T2W, gadofosveset T1W MRI, and gadofosveset T1W MRI + T2W MRI. The general reader scored with and without MPR. Confidence level scores were used to construct receiver-operating characteristic (ROC) curves. Area under the curve (AUC) values and diagnostic parameters were calculated and compared. RESULTS: Gadofosveset T1W MRI + T2W MRI showed slightly superior sensitivity than T2W MRI for the general but not the expert reader. Specificity was higher for the expert on gadofosveset T1W MRI only compared with T2W MRI only (100 % vs. 82 %). MPR did not increase diagnostic performance. Interobserver agreement was highest for the combination of gadofosveset-enhanced T1W imaging plus T2W MRI. CONCLUSIONS: The sole use or addition of gadofosveset-enhanced T1W MRI to T2W MRI did not increase significantly diagnostic performance for assessing ypT0-2 tumours. Adding gadofosveset-enhanced T1W MRI slightly increased sensitivity for the general reader and specificity for the expert reader, but this increase was not significant for more accurate clinical decision making. MPR did not improve diagnostic performance. KEY POINTS: * ycT restaging with MRI in rectal cancer is challenging. * Gadofosveset-enhanced T1W MRI has shown promise for nodal restaging. * Gadofosveset-enhanced T1W MRI did not significantly increase diagnostic performance for assessing ypT0-2-tumours. * Addition of the gadofosveset sequence to T2W MRI slightly increased sensitivity for the general reader. * MPR did not improve diagnostic performance of ycT staging.
Original languageEnglish
Pages (from-to)1845-1852
Number of pages8
JournalEuropean Radiology
Issue number8
Publication statusPublished - Aug 2014


  • Rectal cancer
  • Magnetic resonance imaging
  • Contrast agent
  • Chemoradiotherapy
  • Neoplasm staging

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