Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression

F. Caiment, J. Wolters, E. Smit, Y. Schrooders, J. Kleinjans, T. van den Beucken

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)3463-3473
Number of pages11
JournalArchives of Toxicology
Volume94
Issue number10
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • ccaat/enhancer-binding protein alpha (c/ebp alpha)
  • exposure
  • glutathione
  • hepatotoxicity
  • homeostasis
  • induced liver steatosis
  • lentiviral shrna
  • mechanisms
  • oxygen consumption
  • phosphorylation
  • primary human hepatocytes
  • rna interference
  • steatosis
  • transcription factors
  • transcriptomics
  • valproic acid
  • Transcription factors
  • RNA interference
  • PHOSPHORYLATION
  • TRANSCRIPTOMICS
  • INDUCED LIVER STEATOSIS
  • EXPOSURE
  • HOMEOSTASIS
  • Oxygen consumption
  • MECHANISMS
  • Valproic acid
  • Lentiviral shRNA
  • Steatosis
  • GLUTATHIONE
  • Ccaat/enhancer-binding protein alpha (C/EBP alpha)
  • HEPATOTOXICITY
  • Primary human hepatocytes

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