Validity of the global anti-phospholipid syndrome score to predict thrombosis: a prospective multicentre cohort study

Stephane Zuily*, Bas de Laat, Shirine Mohamed, Hilde Kelchtermans, Zakera Shums, Roger Albesa, Gary L. Norman, Claire Lamboux-Matthieu, Anne-Christine Rat, Jacques Ninet, Nadine Magy-Bertrand, Jean-Louis Pasquali, Marc Lambert, Bernard Lorcerie, Pierre Kaminsky, Francis Guillemin, Veronique Regnault, Denis Wahl

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Objective. To investigate the validity of the global APS score (GAPSS) to predict thrombosis in patients with autoimmune diseases. Methods. This prospective cohort study included consecutive patients with aPL or SLE. aPL, aPS-PT and GAPSS were determined. A Cox proportional hazards model assessed the validity of GAPSS and identified other potential independent predictors of thrombosis. Results. One hundred and thirty-seven patients [43.5 (S.D. 15.4) years old; 107 women] were followed up for a mean duration of 43.1 (S.D. 20.7) months. Mean GAPSS was significantly higher in patients who experienced a thrombotic event compared with those without [10.88 (S.D. 5.06) vs 8.15 (S.D. 5.31), respectively, P = 0.038]. In univariate analysis, age [hazard ratio (HR) = 1.04 (95% CI 1.01, 1.08)] and GAPSS above 16 [HR = 6.86 (95% CI 1.90, 24.77)] were each significantly associated with thrombosis during follow-up, while history of arterial thrombosis [HR = 2.61 (95% CI 0.87, 7.82)] failed to reach significance. Among aPL assays, IgG aPS/PT-a component of the GAPSS-was significantly associated with thrombosis [HR = 2.95 (95% CI 1.02, 8.51)]. In multivariate analysis, GAPSS above 16 remained the only significant predictor of thrombosis [HR = 6.17 (95% CI 1.70, 22.40)]. Conclusion. This first external validation study confirmed that GAPSS can predict thrombosis in patients with aPL and associated autoimmune diseases.
Original languageEnglish
Pages (from-to)2071-2075
Issue number11
Publication statusPublished - Nov 2015


  • antiphospholipid syndrome
  • global APS score
  • anti-phosphatidylserine/prothrombin antibodies
  • systemic lupus erythematosus
  • thrombosis

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