Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats

Ellis Nelissen, Nick P. van Goethem, Vivian T. Bonassoli, Pim R. A. Heckman, Britt T. J. van Hagen, Dila Suay, Caroline Wouters, Jos Prickaerts*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalNeuroscience Letters
Volume699
DOIs
Publication statusPublished - 23 Apr 2019

Keywords

  • alpha 2 adrenergic receptor
  • Emesis
  • Ketamine
  • Xylazine
  • Phosphodiesterase
  • Nausea
  • CERULEUS NORADRENERGIC NEURONS
  • LOCUS-CERULEUS
  • PDE4 INHIBITORS
  • AREA POSTREMA
  • CLONIDINE
  • EMESIS
  • NAUSEA
  • MECHANISMS
  • RECEPTOR
  • RELEASE

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