Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial

R. A. Nout*, V. T. H. B. M. Smit, H. Putter, Ina M. Juergenliemk-Schulz, Jan J. Jobsen, L. C. H. W. Lutgens, Elzbieta M. van der Steen-Banasik, Jan Willem M. Mens, A. Slot, Marika C. Stenfert Kroese, B. N. F. M. van Bunningen, A. C. Ansink, W. L. J. van Putten, C. L. Creutzberg

*Corresponding author for this work

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686 Citations (Web of Science)

Abstract

Background after surgery for intermediate-risk endometrial carcinoma, the vagina is the most frequent site of recurrence. This study established whether vaginal brachytherapy (vbt) is as effective as pelvic external beam radiotherapy (ebrt) in prevention of vaginal recurrence, with fewer adverse effects and improved quality of life.
Original languageEnglish
Pages (from-to)816-823
JournalLancet
Volume375
Issue number9717
DOIs
Publication statusPublished - 6 Mar 2010

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