Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial

R. A. Nout*, V. T. H. B. M. Smit, H. Putter, Ina M. Juergenliemk-Schulz, Jan J. Jobsen, L. C. H. W. Lutgens, Elzbieta M. van der Steen-Banasik, Jan Willem M. Mens, A. Slot, Marika C. Stenfert Kroese, B. N. F. M. van Bunningen, A. C. Ansink, W. L. J. van Putten, C. L. Creutzberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

686 Citations (Web of Science)


Background after surgery for intermediate-risk endometrial carcinoma, the vagina is the most frequent site of recurrence. This study established whether vaginal brachytherapy (vbt) is as effective as pelvic external beam radiotherapy (ebrt) in prevention of vaginal recurrence, with fewer adverse effects and improved quality of life.
Original languageEnglish
Pages (from-to)816-823
Issue number9717
Publication statusPublished - 6 Mar 2010

Cite this