v-ATPase is a key player in lipid-induced cardiomyopathy

Yilin Liu

Research output: ThesisDoctoral ThesisInternal

342 Downloads (Pure)

Abstract

High-fat diet is a key contributor to type 2 diabetes. Typically, people adhering to a high-fat diet are obese and resistant to insulin. In the heart, lipid accumulation leads to cardiac insulin resistance and ultimately contractile dysfunction. CD36 has been identified as the main fatty acid transporter in the heart. In this thesis we discovered that as part of the CD36 translocation machinery, v-ATPase, the proton pump, is a key player in regulation of CD36 translocation. More specifically, v-ATPase becomes inhibited during lipid oversupply, which then directly leads to insulin resistance and contractile dysfunction. High glucose infusion could induce the re-assembly of v-ATPase. Novel therapeutic strategies that would selectively upregulate glucose uptake would be suited to re-activate v-ATPase, thereby combat insulin resistance in the lipid-overloaded diabetic heart.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Glatz, Jan, Supervisor
  • Luiken, Joannes, Advisor
  • Neumann, Dietbert, Advisor
Award date13 Sep 2016
Publisher
Print ISBNs9789090298924
Electronic ISBNs9789090298924
Publication statusPublished - 2016

Keywords

  • type 2 diabetes
  • v-ATPase
  • Insulin resistance

Cite this

Liu, Y. (2016). v-ATPase is a key player in lipid-induced cardiomyopathy. Maastricht University.