Using high spatial resolution fMRI to understand representation in the auditory network

Michelle Moerel*, Essa Yacoub, Omer Faruk Gulban, Agustin Lage-Castellanos, Federico De Martino

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Following rapid methodological advances, ultra-high field (UHF) functional and anatomical magnetic resonance imaging (MRI) has been repeatedly and successfully used for the investigation of the human auditory system in recent years. Here, we review this work and argue that UHF MRI is uniquely suited to shed light on how sounds are represented throughout the network of auditory brain regions. That is, the provided gain in spatial resolution at UHF can be used to study the functional role of the small subcortical auditory processing stages and details of cortical processing. Further, by combining high spatial resolution with the versatility of MRI contrasts, UHF MRI has the potential to localize the primary auditory cortex in individual hemispheres. This is a prerequisite to study how sound representation in higher-level auditory cortex evolves from that in early (primary) auditory cortex. Finally, the access to independent signals across auditory cortical depths, as afforded by UHF, may reveal the computations that underlie the emergence of an abstract, categorical sound representation based on low-level acoustic feature processing. Efforts on these research topics are underway. Here we discuss promises as well as challenges that come with studying these research questions using UHF MRI, and provide a future outlook.

Original languageEnglish
Article number101887
Number of pages14
JournalProgress in Neurobiology
Volume207
Early online date31 Jul 2020
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Ultra-high field MRI
  • Auditory system
  • Subcortical processing
  • Laminar fMRI
  • Sound representation
  • MEDIAL GENICULATE-BODY
  • SPIN-ECHO FMRI
  • INFERIOR COLLICULUS
  • HUMAN BRAIN
  • 7 T
  • GRADIENT-ECHO
  • TONOTOPIC ORGANIZATION
  • LATERAL LEMNISCUS
  • FUNCTIONAL MRI
  • CORTICAL AREAS

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