Use, timing and outcome of coronary angiography in patients with high-risk non-ST-segment elevation acute coronary syndrome in daily clinical practice: insights from a 'real world' prospective registry

E A Badings*, R S Hermanides, A Van Der Sluis, J H E Dambrink, A T M Gosselink, E Kedhi, J P Ottervanger, V Roolvink, W S Remkes, E Van't Riet, H Suryapranata, A W J Van't Hof

*Corresponding author for this work

Research output: Contribution to journalArticleAcademic

5 Citations (Web of Science)

Abstract

BACKGROUND: An early invasive strategy (EIS) is recommended in high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), defined as coronary angiography (CAG), within 24 h of admission. The aim of the present study is to investigate guideline adherence, patient characteristics associated with timing of the intervention and clinical outcome.

METHODS: In a prospective registry, the use and timing of CAG and the characteristics and clinical outcome associated with timing were evaluated in high-risk ACS patients. The outcome of early versus delayed invasive strategy (DIS) was compared.

RESULTS: Between 2006 and 2014, 2,299 high-risk NSTE-ACS patients were included. The use of CAG increased from 77% in 2006 to 90% in 2014 (p trend <0.001) together with a decrease of median time to CAG from 23.3 to 14.5 h (p trend <0.001) and an increase of patients undergoing EIS from 50 to 60% (p trend = 0.002). Patient factors independently related to DIS were higher GRACE risk score, higher age and the presence of comorbidities. No difference was found in incidence of mortality, reinfarction or bleeding at 30-day follow-up. All-cause mortality at 1‑year follow-up was 4.1% vs 7.0% in EIS and DIS respectively (hazard ratio 1.67, 95% confidence interval 1.12-2.49) but was comparable after adjustment for confounding factors.

CONCLUSION: The percentage of high-risk NSTE-ACS patients undergoing CAG and EIS has increased in the last decade. In contrast to the guidelines, patients with a higher risk profile are less likely to undergo EIS. However, no difference in outcome after 30 days and 1 year was found after multivariate adjustment for this higher risk.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalNetherlands Heart Journal
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • Clinical outcome
  • Coronary angiography
  • Delayed invasive strategy
  • Early invasive strategy
  • Non-ST-elevation acute coronary syndrome
  • INVASIVE CARDIAC PROCEDURES
  • ACUTE MYOCARDIAL-INFARCTION
  • GLOBAL REGISTRY
  • 6-MONTH OUTCOMES
  • ELDERLY-PATIENTS
  • FRENCH REGISTRY
  • PARADOXICAL USE
  • STRATEGY
  • MANAGEMENT
  • INTERVENTION

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