Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

Shauna D O'Donovan; Kurt Driessens; Daniel Lopatta; Florian Wimmenauer; Alexander Lukas; Jelmer Neeven; Evgueni Smirnov; Michael Lenz; Gokhan Ertaylan; Danyel G J Jennen; Natal A W van Riel; Rachel Cavill; Ralf L M Peeters; Theo M C M de Kok

doi:10.1371/journal.pone.0236392

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

Shauna D O'Donovan^*, Kurt Driessens, Daniel Lopatta, Florian Wimmenauer, Alexander Lukas, Jelmer Neeven, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G J Jennen, Natal A W van Riel, Rachel Cavill, Ralf L M Peeters, Theo M C M de Kok

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	e0236392
Number of pages	20
Journal	PLOS ONE
Volume	15
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0236392
Publication status	Published - 11 Aug 2020

Keywords

REPRESENTATIONS
TOXICOGENOMICS
TOXICOLOGY
TOXICITY

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10.1371/journal.pone.0236392Licence: CC BY

Cite this

O'Donovan, S. D., Driessens, K., Lopatta, D., Wimmenauer, F., Lukas, A., Neeven, J., Smirnov, E., Lenz, M., Ertaylan, G., Jennen, D. G. J., van Riel, N. A. W., Cavill, R., Peeters, R. L. M., & de Kok, T. M. C. M. (2020). Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes. PLOS ONE, 15(8), [e0236392]. https://doi.org/10.1371/journal.pone.0236392

O'Donovan, Shauna D ; Driessens, Kurt ; Lopatta, Daniel ; Wimmenauer, Florian ; Lukas, Alexander ; Neeven, Jelmer ; Smirnov, Evgueni ; Lenz, Michael ; Ertaylan, Gokhan ; Jennen, Danyel G J ; van Riel, Natal A W ; Cavill, Rachel ; Peeters, Ralf L M ; de Kok, Theo M C M. / Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes. In: PLOS ONE. 2020 ; Vol. 15, No. 8.

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author = "O'Donovan, {Shauna D} and Kurt Driessens and Daniel Lopatta and Florian Wimmenauer and Alexander Lukas and Jelmer Neeven and Evgueni Smirnov and Michael Lenz and Gokhan Ertaylan and Jennen, {Danyel G J} and {van Riel}, {Natal A W} and Rachel Cavill and Peeters, {Ralf L M} and {de Kok}, {Theo M C M}",

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O'Donovan, SD , Driessens, K, Lopatta, D, Wimmenauer, F, Lukas, A, Neeven, J, Smirnov, E, Lenz, M, Ertaylan, G, Jennen, DGJ , van Riel, NAW , Cavill, R , Peeters, RLM & de Kok, TMCM 2020, 'Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes', PLOS ONE, vol. 15, no. 8, e0236392. https://doi.org/10.1371/journal.pone.0236392

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes. / O'Donovan, Shauna D ; Driessens, Kurt; Lopatta, Daniel; Wimmenauer, Florian; Lukas, Alexander; Neeven, Jelmer; Smirnov, Evgueni; Lenz, Michael; Ertaylan, Gokhan; Jennen, Danyel G J ; van Riel, Natal A W ; Cavill, Rachel ; Peeters, Ralf L M ; de Kok, Theo M C M.

In: PLOS ONE, Vol. 15, No. 8, e0236392, 11.08.2020.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Lenz, Michael

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AU - Jennen, Danyel G J

AU - van Riel, Natal A W

AU - Cavill, Rachel

AU - Peeters, Ralf L M

AU - de Kok, Theo M C M

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