Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

Shauna D O'Donovan; Kurt Driessens; Daniel Lopatta; Florian Wimmenauer; Alexander Lukas; Jelmer Neeven; Tobias Stumm; Evgueni Smirnov; Michael Lenz; Gokhan Ertaylan; Danyel G J Jennen; Natal A W van Riel; Rachel Cavill; Ralf L M Peeters; Theo M C M de Kok

doi:10.1371/journal.pone.0236392

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

Shauna D O'Donovan^*, Kurt Driessens, Daniel Lopatta, Florian Wimmenauer, Alexander Lukas, Jelmer Neeven, Tobias Stumm, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G J Jennen, Natal A W van Riel, Rachel Cavill, Ralf L M Peeters, Theo M C M de Kok

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	e0236392
Number of pages	20
Journal	PLOS ONE
Volume	15
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0236392 https://doi.org/10.1371/journal.pone.0236392
Publication status	Published - 11 Aug 2020

Keywords

REPRESENTATIONS
TOXICOGENOMICS
TOXICOLOGY
TOXICITY

Access to Document

Cite this

O'Donovan, S. D., Driessens, K., Lopatta, D., Wimmenauer, F., Lukas, A., Neeven, J., Stumm, T., Smirnov, E., Lenz, M., Ertaylan, G., Jennen, D. G. J., van Riel, N. A. W., Cavill, R., Peeters, R. L. M., & de Kok, T. M. C. M. (2020). Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes. PLOS ONE, 15(8), [e0236392]. https://doi.org/10.1371/journal.pone.0236392, https://doi.org/10.1371/journal.pone.0236392

O'Donovan, Shauna D ; Driessens, Kurt ; Lopatta, Daniel ; Wimmenauer, Florian ; Lukas, Alexander ; Neeven, Jelmer ; Stumm, Tobias ; Smirnov, Evgueni ; Lenz, Michael ; Ertaylan, Gokhan ; Jennen, Danyel G J ; van Riel, Natal A W ; Cavill, Rachel ; Peeters, Ralf L M ; de Kok, Theo M C M. / Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes. In: PLOS ONE. 2020 ; Vol. 15, No. 8.

@article{0aeb482bc57a49cfa29647bf5223a69c,

title = "Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes",

keywords = "REPRESENTATIONS, TOXICOGENOMICS, TOXICOLOGY, TOXICITY",

author = "O'Donovan, {Shauna D} and Kurt Driessens and Daniel Lopatta and Florian Wimmenauer and Alexander Lukas and Jelmer Neeven and Tobias Stumm and Evgueni Smirnov and Michael Lenz and Gokhan Ertaylan and Jennen, {Danyel G J} and {van Riel}, {Natal A W} and Rachel Cavill and Peeters, {Ralf L M} and {de Kok}, {Theo M C M}",

year = "2020",

month = aug,

day = "11",

doi = "10.1371/journal.pone.0236392",

language = "English",

volume = "15",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

O'Donovan, SD , Driessens, K, Lopatta, D, Wimmenauer, F, Lukas, A, Neeven, J, Stumm, T, Smirnov, E , Lenz, M, Ertaylan, G, Jennen, DGJ, van Riel, NAW, Cavill, R , Peeters, RLM & de Kok, TMCM 2020, 'Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes', PLOS ONE, vol. 15, no. 8, e0236392. https://doi.org/10.1371/journal.pone.0236392, https://doi.org/10.1371/journal.pone.0236392

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes. / O'Donovan, Shauna D ; Driessens, Kurt; Lopatta, Daniel; Wimmenauer, Florian; Lukas, Alexander; Neeven, Jelmer; Stumm, Tobias; Smirnov, Evgueni ; Lenz, Michael; Ertaylan, Gokhan; Jennen, Danyel G J; van Riel, Natal A W; Cavill, Rachel ; Peeters, Ralf L M ; de Kok, Theo M C M.

In: PLOS ONE, Vol. 15, No. 8, e0236392, 11.08.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

AU - O'Donovan, Shauna D

AU - Driessens, Kurt

AU - Lopatta, Daniel

AU - Wimmenauer, Florian

AU - Lukas, Alexander

AU - Neeven, Jelmer

AU - Stumm, Tobias

AU - Smirnov, Evgueni

AU - Lenz, Michael

AU - Ertaylan, Gokhan

AU - Jennen, Danyel G J

AU - van Riel, Natal A W

AU - Cavill, Rachel

AU - Peeters, Ralf L M

AU - de Kok, Theo M C M

PY - 2020/8/11

Y1 - 2020/8/11

KW - REPRESENTATIONS

KW - TOXICOGENOMICS

KW - TOXICOLOGY

KW - TOXICITY

U2 - 10.1371/journal.pone.0236392

DO - 10.1371/journal.pone.0236392

M3 - Article

C2 - 32780735

VL - 15

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 8

M1 - e0236392

ER -