Use of "C9/11 Mismatch" Control Small Interfering RNA Reveals Sequence-Related Off-Target Effect on Coagulation of an Small Interfering RNA Targeting Mouse Coagulation Factor XII

Marco Heestermans, Annika de Jong, Sander van Tilburg, Pieter H. Reitsma, Henri H. Versteeg, Henri M. Spronk, Bart J. M. van Vlijmen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalNucleic Acid Therapeutics
Volume29
Issue number4
DOIs
Publication statusPublished - Aug 2019

Keywords

  • coagulation factor XII
  • siRNA
  • mouse
  • coagulation
  • off-target effect
  • SPONTANEOUS VENOUS THROMBOSIS
  • GENERATION
  • ACTIVATION
  • NEUTROPHILS
  • PLATELETS

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