Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart

Dimosthenis Giamouridis; Mei Hua Gao; N. Chin Lai; Zhen Tan; Young Chul Kim; Tracy Guo; Atsushi Miyanohara; Matthijs W. Blankesteijn; Erik A. L. Biessen; H. Kirk Hammond

doi:10.1089/hum.2018.103

Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart

Dimosthenis Giamouridis, Mei Hua Gao, N. Chin Lai, Zhen Tan, Young Chul Kim, Tracy Guo, Atsushi Miyanohara, Matthijs W. Blankesteijn, Erik A. L. Biessen, H. Kirk Hammond^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

66 Downloads (Pure)

Abstract

Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. This study asked whether UCn3 gene transfer, which provides sustained elevation of plasma UCn3 levels, increases the function of the failing heart. HF was induced by transmural left ventricular (LV) cryoinjury in mice. LV function was assessed 3 weeks later by echocardiography. Those with ejection fractions (EF)

Original language	English
Pages (from-to)	10-20
Number of pages	11
Journal	Human Gene Therapy
Volume	30
Issue number	1
DOIs	https://doi.org/10.1089/hum.2018.103
Publication status	Published - Jan 2019

Keywords

gene therapy
heart failure with reduced EF
SERCA2a
AAV8
ADENOASSOCIATED VIRUS VECTORS
MYOCARDIAL-INFARCTION
FAILURE
PHARMACOKINETICS
DYSFUNCTION
EXPRESSION
MUSCLE
MOUSE

Access to Document

10.1089/hum.2018.103

Full TextFinal published version, 748 KBLicence: Taverne

Cite this

@article{4d752fe3a7a24f49bb2d1586f12fdb4c,

title = "Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart",

abstract = "Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. This study asked whether UCn3 gene transfer, which provides sustained elevation of plasma UCn3 levels, increases the function of the failing heart. HF was induced by transmural left ventricular (LV) cryoinjury in mice. LV function was assessed 3 weeks later by echocardiography. Those with ejection fractions (EF)",

keywords = "gene therapy, heart failure with reduced EF, SERCA2a, AAV8, ADENOASSOCIATED VIRUS VECTORS, MYOCARDIAL-INFARCTION, FAILURE, PHARMACOKINETICS, DYSFUNCTION, EXPRESSION, MUSCLE, MOUSE",

author = "Dimosthenis Giamouridis and Gao, {Mei Hua} and Lai, {N. Chin} and Zhen Tan and Kim, {Young Chul} and Tracy Guo and Atsushi Miyanohara and Blankesteijn, {Matthijs W.} and Biessen, {Erik A. L.} and Hammond, {H. Kirk}",

note = "Funding Information: This work was supported by National Institutes of Health grant (P01 HL66941) and Merit grants from the Department of Veteran's Affairs (1101 BX001515 and 1I01 BX003774) Funding Information: This work was supported by National Institutes of Health grant (P01 HL66941) and Merit grants from the Department of Veteran{\textquoteright}s Affairs (1101 BX001515 and 1I01 BX003774). Publisher Copyright: {\textcopyright} Copyright 2019, Mary Ann Liebert, Inc.",

year = "2019",

month = jan,

doi = "10.1089/hum.2018.103",

language = "English",

volume = "30",

pages = "10--20",

journal = "Human Gene Therapy",

issn = "1043-0342",

publisher = "Mary Ann Liebert Inc.",

number = "1",

}

TY - JOUR

T1 - Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart

AU - Giamouridis, Dimosthenis

AU - Gao, Mei Hua

AU - Lai, N. Chin

AU - Tan, Zhen

AU - Kim, Young Chul

AU - Guo, Tracy

AU - Miyanohara, Atsushi

AU - Blankesteijn, Matthijs W.

AU - Biessen, Erik A. L.

AU - Hammond, H. Kirk

N1 - Funding Information: This work was supported by National Institutes of Health grant (P01 HL66941) and Merit grants from the Department of Veteran's Affairs (1101 BX001515 and 1I01 BX003774) Funding Information: This work was supported by National Institutes of Health grant (P01 HL66941) and Merit grants from the Department of Veteran’s Affairs (1101 BX001515 and 1I01 BX003774). Publisher Copyright: © Copyright 2019, Mary Ann Liebert, Inc.

PY - 2019/1

Y1 - 2019/1

N2 - Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. This study asked whether UCn3 gene transfer, which provides sustained elevation of plasma UCn3 levels, increases the function of the failing heart. HF was induced by transmural left ventricular (LV) cryoinjury in mice. LV function was assessed 3 weeks later by echocardiography. Those with ejection fractions (EF)

AB - Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chronic therapy. This study asked whether UCn3 gene transfer, which provides sustained elevation of plasma UCn3 levels, increases the function of the failing heart. HF was induced by transmural left ventricular (LV) cryoinjury in mice. LV function was assessed 3 weeks later by echocardiography. Those with ejection fractions (EF)

KW - gene therapy

KW - heart failure with reduced EF

KW - SERCA2a

KW - AAV8

KW - ADENOASSOCIATED VIRUS VECTORS

KW - MYOCARDIAL-INFARCTION

KW - FAILURE

KW - PHARMACOKINETICS

KW - DYSFUNCTION

KW - EXPRESSION

KW - MUSCLE

KW - MOUSE

U2 - 10.1089/hum.2018.103

DO - 10.1089/hum.2018.103

M3 - Article

SN - 1043-0342

VL - 30

SP - 10

EP - 20

JO - Human Gene Therapy

JF - Human Gene Therapy

IS - 1

ER -

Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart

Abstract

Keywords

Access to Document

Fingerprint

Cite this