Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants

Francesco M. Risso, Laura D. Serpero, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Rosanna Frulio, Fabrizio Michetti, Pasquale Florio, Moataza Bashir, Iman Iskander, Hala Mufeed, Hanna Aboulgar, Diego Gazzolo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

Aim To investigate whether S100A1B and BB dimers are predictors of early perinatal death in newborns with perinatal asphyxia (PA). Methods The study compared 38 full-term newborns with PA [neonatal death n=11; hypoxic ischaemic encephalopathy (HIE): n=27] with a control group of 38 healthy infants. Clinical and laboratory parameters were recordedat eight time points and urine collected for S100B assessment. Multivariate analysis was performed in order to analyse the influence of various clinical parameters on the occurrence of neonatal death. Results A1B and BB in PA nonsurvivor infants were significantly higher (p42ng/L) was the best predictor of early neonatal death (p
Original languageEnglish
Pages (from-to)E467-E472
JournalActa Paediatrica
Volume102
Issue number10
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Asphyxia
  • Hypoxic ischaemic encephalopathy
  • Neonatal death
  • S100A1B
  • S100BB

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