Urinary peptidomic biomarkers of renal function in heart transplant recipients

Qi-Fang Huang, Zhen-Yu Zhang, Jan Van Keer, Sander Trenson, Esther Nkuipou-Kenfack, Wen-Yi Yang, Lutgarde Thijs, Johan Vanhaecke, Lucas N. L. Van Aelst, Johan Van Cleemput, Stefan Janssens, Peter Verhamme, Harald Mischak, Jan A. Staessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Background. Chronic kidney disease (CKD) is common in patients after heart transplantation (HTx). We assessed whether in HTx recipients the proteomic urinary classifier CKD273 or sequenced urinary peptides revealing the parental proteins correlated with the estimated glomerular filtration rate (eGFR).

Methods. In 368 HTx patients, we measured the urinary peptidome and analysed CKD273 and 48 urinary peptides with a detectable signal in >95% of participants. After 9.1months (median), eGFR and the urinary biomarkers were reassessed.

Results. In multivariable Bonferroni-corrected analyses of the baseline data, a 1-SD increase in CKD273 was associated with a 11.4 [95% confidence interval (CI) 7.25-15.5] mL/min/1.73m(2) lower eGFR and an odds ratio of 2.63 (1.56-4.46) for having eGFR

Conclusions. With the exception of baseline eGFR, CKD273 was more closer associated with imminent renal dysfunction than 24-h proteinuria. Fragments of collagen I and mucin-1-respectively, positively and inversely associated with eGFR and change in eGFR-are single-peptide markers associated with renal dysfunction.

Original languageEnglish
Pages (from-to)1336-1343
Number of pages8
JournalNephrology Dialysis Transplantation
Volume34
Issue number8
DOIs
Publication statusPublished - Aug 2019

Keywords

  • DIAGNOSIS
  • DISEASE
  • EXPRESSION
  • KIDNEY
  • MANAGEMENT
  • MUC1
  • MUTATIONS
  • PREDICTION
  • PROTEOME
  • SERUM
  • collagen
  • glomerular filtration
  • heart transplantation
  • mucin-1
  • urinary proteomics
  • KL-6

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