Abstract

Objective:Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure and hypertension.Methods:Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.08.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension.Results:After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81mol/l) was associated with higher 24-h MAP [ 0.63mmHg; confidence interval (CI) 0.27-1.00] and positively associated with hypertension (odds ratio 1.43; CI 1.27-1.61). Urinary uric acid excretion (per SD of 140mg/day/1.73m(2)) was associated with higher 24-h MAP ( 0.79mmHg; CI 0.46-1.12) and with hypertension (odds ratio 1.13; CI 1.02-1.25). There was no significant association between serum and 24-h urinary uric acid excretion with 24-h pulse pressure. There was no interaction with sex or age for the aforementioned associations.Conclusion:Higher serum and urinary uric acid concentrations were associated with higher 24-h MAP and hypertension. These results suggest that serum and 24-urinary uric acid concentrations, the latter as proxy for uric acid production are, independent of each other, associated with BP and hypertension.

Original languageEnglish
Pages (from-to)1968-1975
Number of pages8
JournalJournal of Hypertension
Volume35
Issue number10
DOIs
Publication statusPublished - Oct 2017

Keywords

  • blood pressure
  • hypertension
  • mean arterial pressure
  • pulse pressure
  • reactive oxygen species
  • uric acid
  • xanthine dehydrogenase
  • xanthine oxidase
  • xanthine oxidoreductase
  • ABCG2 DYSFUNCTION INCREASES
  • RENIN-ANGIOTENSIN SYSTEM
  • CORONARY HEART-DISEASE
  • ARTERIAL STIFFNESS
  • PULSE PRESSURE
  • INCIDENT HYPERTENSION
  • GENERAL-POPULATION
  • OXIDATIVE STRESS
  • EUROPEAN-SOCIETY
  • XANTHINE-OXIDASE

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