Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide

Sibel Altintas; Eline Cardinaels; Mathijs O. Versteylen; Ivo A. Joosen; H. Seifert; Joachim E. Wildberger; Harry J. Crijns; Patricia J. Nelemans; Marja P. van Dieijen - Visser; Alma M. A. Mingels; Marco Das; Bas L. Kietselaer

doi:10.1016/j.jcct.2015.10.001

Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide

Sibel Altintas, Eline Cardinaels, Mathijs O. Versteylen, Ivo A. Joosen, H. Seifert, Joachim E. Wildberger, Harry J. Crijns, Patricia J. Nelemans, Marja P. van Dieijen - Visser, Alma M. A. Mingels, Marco Das, Bas L. Kietselaer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Web of Science)

Abstract

Background: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. Objective: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. Methods: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. Results: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values

Original language	English
Pages (from-to)	82-88
Journal	Journal of Cardiovascular Computed Tomography
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.jcct.2015.10.001
Publication status	Published - 2016

Keywords

Coronary CT angiography
Coronary plaque
Plaque volume
Plaque burden
Plaque quantification
Quantitative coronary tree analysis
Biological markers
Cardiac troponin
Natriuretic peptide

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10.1016/j.jcct.2015.10.001

Cite this

Altintas, S., Cardinaels, E., Versteylen, M. O., Joosen, I. A., Seifert, H., Wildberger, J. E., Crijns, H. J., Nelemans, P. J., van Dieijen - Visser, M. P., Mingels, A. M. A., Das, M., & Kietselaer, B. L. (2016). Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide. Journal of Cardiovascular Computed Tomography, 10(1), 82-88. https://doi.org/10.1016/j.jcct.2015.10.001

@article{c179b02dadb94b4faaead7e2e210a6c9,

title = "Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide",

abstract = "Background: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. Objective: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. Methods: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ({"}Sum plaque score{"}) incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. Results: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values ",

keywords = "Coronary CT angiography, Coronary plaque, Plaque volume, Plaque burden, Plaque quantification, Quantitative coronary tree analysis, Biological markers, Cardiac troponin, Natriuretic peptide",

author = "Sibel Altintas and Eline Cardinaels and Versteylen, {Mathijs O.} and Joosen, {Ivo A.} and H. Seifert and Wildberger, {Joachim E.} and Crijns, {Harry J.} and Nelemans, {Patricia J.} and {van Dieijen - Visser}, {Marja P.} and Mingels, {Alma M. A.} and Marco Das and Kietselaer, {Bas L.}",

year = "2016",

doi = "10.1016/j.jcct.2015.10.001",

language = "English",

volume = "10",

pages = "82--88",

journal = "Journal of Cardiovascular Computed Tomography",

issn = "1934-5925",

publisher = "Elsevier Inc.",

number = "1",

}

Altintas, S, Cardinaels, E, Versteylen, MO, Joosen, IA, Seifert, H, Wildberger, JE , Crijns, HJ , Nelemans, PJ, van Dieijen - Visser, MP, Mingels, AMA, Das, M & Kietselaer, BL 2016, 'Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide', Journal of Cardiovascular Computed Tomography, vol. 10, no. 1, pp. 82-88. https://doi.org/10.1016/j.jcct.2015.10.001

Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide. / Altintas, Sibel; Cardinaels, Eline; Versteylen, Mathijs O. et al.

In: Journal of Cardiovascular Computed Tomography, Vol. 10, No. 1, 2016, p. 82-88.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide

AU - Altintas, Sibel

AU - Cardinaels, Eline

AU - Versteylen, Mathijs O.

AU - Joosen, Ivo A.

AU - Seifert, H.

AU - Wildberger, Joachim E.

AU - Crijns, Harry J.

AU - Nelemans, Patricia J.

AU - van Dieijen - Visser, Marja P.

AU - Mingels, Alma M. A.

AU - Das, Marco

AU - Kietselaer, Bas L.

PY - 2016

Y1 - 2016

N2 - Background: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. Objective: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. Methods: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. Results: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values

AB - Background: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. Objective: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. Methods: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. Results: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values

KW - Coronary CT angiography

KW - Coronary plaque

KW - Plaque volume

KW - Plaque burden

KW - Plaque quantification

KW - Quantitative coronary tree analysis

KW - Biological markers

KW - Cardiac troponin

KW - Natriuretic peptide

U2 - 10.1016/j.jcct.2015.10.001

DO - 10.1016/j.jcct.2015.10.001

M3 - Article

C2 - 26481512

VL - 10

SP - 82

EP - 88

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

IS - 1

ER -