Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide

Sibel Altintas, Eline Cardinaels, Mathijs O. Versteylen, Ivo A. Joosen, H. Seifert, Joachim E. Wildberger, Harry J. Crijns, Patricia J. Nelemans, Marja P. van Dieijen - Visser, Alma M. A. Mingels, Marco Das, Bas L. Kietselaer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. Objective: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. Methods: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. Results: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values
Original languageEnglish
Pages (from-to)82-88
JournalJournal of Cardiovascular Computed Tomography
Issue number1
Publication statusPublished - 2016


  • Coronary CT angiography
  • Coronary plaque
  • Plaque volume
  • Plaque burden
  • Plaque quantification
  • Quantitative coronary tree analysis
  • Biological markers
  • Cardiac troponin
  • Natriuretic peptide

Cite this