Unraveling the Biopsychosocial Factors of Fatigue and Sleep Problems After Traumatic Brain Injury: Protocol for a Multicenter Longitudinal Cohort Study

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Abstract

BACKGROUND: Fatigue and sleep problems are common after a traumatic brain injury (TBI) and are experienced as highly distressing symptoms, playing a significant role in the recovery trajectory, and they can drastically impact the quality of life and societal participation of the patient and their family and friends. However, the etiology and development of these symptoms are still uncertain.

OBJECTIVE: The aim of this study is to examine the development of fatigue and sleep problems following moderate to severe TBI and to explore the changes in underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors across time.

METHODS: This study is a longitudinal multicenter observational cohort study with 4 measurement points (3, 6, 12, and 18 months postinjury) including subjective questionnaires and cognitive tasks, preceded by 7 nights of actigraphy combined with a sleep diary. Recruitment of 137 moderate to severe TBI patients presenting at emergency and neurology departments or rehabilitation centers across the Netherlands is anticipated. The evolution of fatigue and sleep problems following TBI and their association with possible underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors will be examined.

RESULTS: Recruitment of participants for this longitudinal cohort study started in October 2017, and the enrollment of participants is ongoing. The first results are expected at the end of 2020.

CONCLUSIONS: To the authors' knowledge, this is the first study that examines the development of both post-TBI fatigue and sleep longitudinally within a biopsychosocial model in moderate to severe TBI using both subjective and objective measures. Identification of modifiable factors such as mood and psychosocial stressors may give direction to the development of interventions for fatigue and sleep problems post-TBI.

TRIAL REGISTRATION: Netherlands Trial Register NTR7162; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=7162 (Archived by WebCite at http://www.webcitation.org/6z3mvNLuy).

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/11295.

Original languageEnglish
Article numbere11295
Pages (from-to)137-148
Number of pages12
JournalJMIR Research Protocols
Volume7
Issue number10
DOIs
Publication statusPublished - 22 Oct 2018

Keywords

  • traumatic brain injury
  • sleep
  • fatigue
  • biopsychosocial model
  • POSTTRAUMATIC-STRESS-DISORDER
  • VISUAL ANALOG SCALE
  • 1ST 2 YEARS
  • EXECUTIVE DYSFUNCTION
  • WAKE DISTURBANCES
  • UTRECHT SCALE
  • RATING-SCALE
  • IMPACT
  • PARTICIPATION
  • PERFORMANCE

Cite this

@article{2931b36e3cc04bbeb99925f912aae6e2,
title = "Unraveling the Biopsychosocial Factors of Fatigue and Sleep Problems After Traumatic Brain Injury: Protocol for a Multicenter Longitudinal Cohort Study",
abstract = "BACKGROUND: Fatigue and sleep problems are common after a traumatic brain injury (TBI) and are experienced as highly distressing symptoms, playing a significant role in the recovery trajectory, and they can drastically impact the quality of life and societal participation of the patient and their family and friends. However, the etiology and development of these symptoms are still uncertain.OBJECTIVE: The aim of this study is to examine the development of fatigue and sleep problems following moderate to severe TBI and to explore the changes in underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors across time.METHODS: This study is a longitudinal multicenter observational cohort study with 4 measurement points (3, 6, 12, and 18 months postinjury) including subjective questionnaires and cognitive tasks, preceded by 7 nights of actigraphy combined with a sleep diary. Recruitment of 137 moderate to severe TBI patients presenting at emergency and neurology departments or rehabilitation centers across the Netherlands is anticipated. The evolution of fatigue and sleep problems following TBI and their association with possible underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors will be examined.RESULTS: Recruitment of participants for this longitudinal cohort study started in October 2017, and the enrollment of participants is ongoing. The first results are expected at the end of 2020.CONCLUSIONS: To the authors' knowledge, this is the first study that examines the development of both post-TBI fatigue and sleep longitudinally within a biopsychosocial model in moderate to severe TBI using both subjective and objective measures. Identification of modifiable factors such as mood and psychosocial stressors may give direction to the development of interventions for fatigue and sleep problems post-TBI.TRIAL REGISTRATION: Netherlands Trial Register NTR7162; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=7162 (Archived by WebCite at http://www.webcitation.org/6z3mvNLuy).INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/11295.",
keywords = "traumatic brain injury, sleep, fatigue, biopsychosocial model, POSTTRAUMATIC-STRESS-DISORDER, VISUAL ANALOG SCALE, 1ST 2 YEARS, EXECUTIVE DYSFUNCTION, WAKE DISTURBANCES, UTRECHT SCALE, RATING-SCALE, IMPACT, PARTICIPATION, PERFORMANCE",
author = "Jessica Bruijel and Stapert, {Sven Z} and Annemiek Vermeeren and Ponsford, {Jennie L} and {van Heugten}, {Caroline M}",
note = "{\circledC}Jessica Bruijel, Sven Z Stapert, Annemiek Vermeeren, Jennie L Ponsford, Caroline M van Heugten. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 22.10.2018.",
year = "2018",
month = "10",
day = "22",
doi = "10.2196/11295",
language = "English",
volume = "7",
pages = "137--148",
journal = "JMIR Research Protocols",
issn = "1929-0748",
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}

TY - JOUR

T1 - Unraveling the Biopsychosocial Factors of Fatigue and Sleep Problems After Traumatic Brain Injury

T2 - Protocol for a Multicenter Longitudinal Cohort Study

AU - Bruijel, Jessica

AU - Stapert, Sven Z

AU - Vermeeren, Annemiek

AU - Ponsford, Jennie L

AU - van Heugten, Caroline M

N1 - ©Jessica Bruijel, Sven Z Stapert, Annemiek Vermeeren, Jennie L Ponsford, Caroline M van Heugten. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 22.10.2018.

PY - 2018/10/22

Y1 - 2018/10/22

N2 - BACKGROUND: Fatigue and sleep problems are common after a traumatic brain injury (TBI) and are experienced as highly distressing symptoms, playing a significant role in the recovery trajectory, and they can drastically impact the quality of life and societal participation of the patient and their family and friends. However, the etiology and development of these symptoms are still uncertain.OBJECTIVE: The aim of this study is to examine the development of fatigue and sleep problems following moderate to severe TBI and to explore the changes in underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors across time.METHODS: This study is a longitudinal multicenter observational cohort study with 4 measurement points (3, 6, 12, and 18 months postinjury) including subjective questionnaires and cognitive tasks, preceded by 7 nights of actigraphy combined with a sleep diary. Recruitment of 137 moderate to severe TBI patients presenting at emergency and neurology departments or rehabilitation centers across the Netherlands is anticipated. The evolution of fatigue and sleep problems following TBI and their association with possible underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors will be examined.RESULTS: Recruitment of participants for this longitudinal cohort study started in October 2017, and the enrollment of participants is ongoing. The first results are expected at the end of 2020.CONCLUSIONS: To the authors' knowledge, this is the first study that examines the development of both post-TBI fatigue and sleep longitudinally within a biopsychosocial model in moderate to severe TBI using both subjective and objective measures. Identification of modifiable factors such as mood and psychosocial stressors may give direction to the development of interventions for fatigue and sleep problems post-TBI.TRIAL REGISTRATION: Netherlands Trial Register NTR7162; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=7162 (Archived by WebCite at http://www.webcitation.org/6z3mvNLuy).INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/11295.

AB - BACKGROUND: Fatigue and sleep problems are common after a traumatic brain injury (TBI) and are experienced as highly distressing symptoms, playing a significant role in the recovery trajectory, and they can drastically impact the quality of life and societal participation of the patient and their family and friends. However, the etiology and development of these symptoms are still uncertain.OBJECTIVE: The aim of this study is to examine the development of fatigue and sleep problems following moderate to severe TBI and to explore the changes in underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors across time.METHODS: This study is a longitudinal multicenter observational cohort study with 4 measurement points (3, 6, 12, and 18 months postinjury) including subjective questionnaires and cognitive tasks, preceded by 7 nights of actigraphy combined with a sleep diary. Recruitment of 137 moderate to severe TBI patients presenting at emergency and neurology departments or rehabilitation centers across the Netherlands is anticipated. The evolution of fatigue and sleep problems following TBI and their association with possible underlying biological (pain, brain damage), psychological (emotional state), and social (support family, participation) factors will be examined.RESULTS: Recruitment of participants for this longitudinal cohort study started in October 2017, and the enrollment of participants is ongoing. The first results are expected at the end of 2020.CONCLUSIONS: To the authors' knowledge, this is the first study that examines the development of both post-TBI fatigue and sleep longitudinally within a biopsychosocial model in moderate to severe TBI using both subjective and objective measures. Identification of modifiable factors such as mood and psychosocial stressors may give direction to the development of interventions for fatigue and sleep problems post-TBI.TRIAL REGISTRATION: Netherlands Trial Register NTR7162; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=7162 (Archived by WebCite at http://www.webcitation.org/6z3mvNLuy).INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/11295.

KW - traumatic brain injury

KW - sleep

KW - fatigue

KW - biopsychosocial model

KW - POSTTRAUMATIC-STRESS-DISORDER

KW - VISUAL ANALOG SCALE

KW - 1ST 2 YEARS

KW - EXECUTIVE DYSFUNCTION

KW - WAKE DISTURBANCES

KW - UTRECHT SCALE

KW - RATING-SCALE

KW - IMPACT

KW - PARTICIPATION

KW - PERFORMANCE

U2 - 10.2196/11295

DO - 10.2196/11295

M3 - Article

C2 - 30348629

VL - 7

SP - 137

EP - 148

JO - JMIR Research Protocols

JF - JMIR Research Protocols

SN - 1929-0748

IS - 10

M1 - e11295

ER -