Understanding the discrepancies between 31 P MR spectroscopy assessed liver metabilite concentrations from different institutions

P.E. Sijens, P.C. Dagnelie, S. Halfwerk, P.J. van Dijk, K. Wicklow, M. Oudkerk

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The high divergence between the liver metabolite concentrations and ph values reported in previous quantitative 31p magnetic resonance studies, for instance phosphomonoester (0.7–3.8 mm) and phosphodiester (3.5–9.7 mm), has not been addressed in the literature. To assess what level of discrepancy can be caused by processing and metabolite integration, in this study chemical shift imaging localized 31p magnetic resonance spectra of human liver were quantitated by three methods currently applied in clinical practice: peak areas defined manually by placement of two cursors vs. Frequency domain curve fitting with the assumption of either gaussian or lorentzian line shapes. Large reproducible differences were found in liver metabolite peak areas but not in ph, indicating that processing and peak integration methods can only explain part of the discrepancies between the results from different institutions.
Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalMagnetic Resonance Imaging
Volume16
DOIs
Publication statusPublished - 1 Jan 1998

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