Understanding the discrepancies between 31 P MR spectroscopy assessed liver metabilite concentrations from different institutions

P.E. Sijens; P.C. Dagnelie; S. Halfwerk; P.J. van Dijk; K. Wicklow; M. Oudkerk

doi:10.1016/S0730-725X(97)00246-4

Understanding the discrepancies between 31 P MR spectroscopy assessed liver metabilite concentrations from different institutions

P.E. Sijens^*, P.C. Dagnelie, S. Halfwerk, P.J. van Dijk, K. Wicklow, M. Oudkerk

^*Corresponding author for this work

NUTRIM - Institute of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The high divergence between the liver metabolite concentrations and ph values reported in previous quantitative 31p magnetic resonance studies, for instance phosphomonoester (0.7–3.8 mm) and phosphodiester (3.5–9.7 mm), has not been addressed in the literature. To assess what level of discrepancy can be caused by processing and metabolite integration, in this study chemical shift imaging localized 31p magnetic resonance spectra of human liver were quantitated by three methods currently applied in clinical practice: peak areas defined manually by placement of two cursors vs. Frequency domain curve fitting with the assumption of either gaussian or lorentzian line shapes. Large reproducible differences were found in liver metabolite peak areas but not in ph, indicating that processing and peak integration methods can only explain part of the discrepancies between the results from different institutions.

Original language	English
Pages (from-to)	205-211
Number of pages	7
Journal	Magnetic Resonance Imaging
Volume	16
DOIs	https://doi.org/10.1016/S0730-725X(97)00246-4
Publication status	Published - 1 Jan 1998

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title = "Understanding the discrepancies between 31 P MR spectroscopy assessed liver metabilite concentrations from different institutions",

abstract = "The high divergence between the liver metabolite concentrations and ph values reported in previous quantitative 31p magnetic resonance studies, for instance phosphomonoester (0.7–3.8 mm) and phosphodiester (3.5–9.7 mm), has not been addressed in the literature. To assess what level of discrepancy can be caused by processing and metabolite integration, in this study chemical shift imaging localized 31p magnetic resonance spectra of human liver were quantitated by three methods currently applied in clinical practice: peak areas defined manually by placement of two cursors vs. Frequency domain curve fitting with the assumption of either gaussian or lorentzian line shapes. Large reproducible differences were found in liver metabolite peak areas but not in ph, indicating that processing and peak integration methods can only explain part of the discrepancies between the results from different institutions.",

author = "P.E. Sijens and P.C. Dagnelie and S. Halfwerk and {van Dijk}, P.J. and K. Wicklow and M. Oudkerk",

year = "1998",

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doi = "10.1016/S0730-725X(97)00246-4",

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T1 - Understanding the discrepancies between 31 P MR spectroscopy assessed liver metabilite concentrations from different institutions

AU - Sijens, P.E.

AU - Dagnelie, P.C.

AU - Halfwerk, S.

AU - van Dijk, P.J.

AU - Wicklow, K.

AU - Oudkerk, M.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The high divergence between the liver metabolite concentrations and ph values reported in previous quantitative 31p magnetic resonance studies, for instance phosphomonoester (0.7–3.8 mm) and phosphodiester (3.5–9.7 mm), has not been addressed in the literature. To assess what level of discrepancy can be caused by processing and metabolite integration, in this study chemical shift imaging localized 31p magnetic resonance spectra of human liver were quantitated by three methods currently applied in clinical practice: peak areas defined manually by placement of two cursors vs. Frequency domain curve fitting with the assumption of either gaussian or lorentzian line shapes. Large reproducible differences were found in liver metabolite peak areas but not in ph, indicating that processing and peak integration methods can only explain part of the discrepancies between the results from different institutions.

AB - The high divergence between the liver metabolite concentrations and ph values reported in previous quantitative 31p magnetic resonance studies, for instance phosphomonoester (0.7–3.8 mm) and phosphodiester (3.5–9.7 mm), has not been addressed in the literature. To assess what level of discrepancy can be caused by processing and metabolite integration, in this study chemical shift imaging localized 31p magnetic resonance spectra of human liver were quantitated by three methods currently applied in clinical practice: peak areas defined manually by placement of two cursors vs. Frequency domain curve fitting with the assumption of either gaussian or lorentzian line shapes. Large reproducible differences were found in liver metabolite peak areas but not in ph, indicating that processing and peak integration methods can only explain part of the discrepancies between the results from different institutions.

U2 - 10.1016/S0730-725X(97)00246-4

DO - 10.1016/S0730-725X(97)00246-4

M3 - Article

SN - 0730-725X

VL - 16

SP - 205

EP - 211

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

ER -

Understanding the discrepancies between 31 P MR spectroscopy assessed liver metabilite concentrations from different institutions

Abstract

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