Understanding regulation of gene transcription through epigenomics and cistromics : unfolding ones and zeros into (un)folding chromatin

Research output: ThesisDoctoral ThesisInternal

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Modern measuring technologies, such as microarray and sequencing technology, have resulted in an explosion of information in biomedical research. The big challenge for a bioinformatician is to develop computer procedures to distil biology from this bunch of ones and zeros. This dissertation crossed bioinformatics with epigenetics, the field that studies the form, not the content, of the genetic material we carry with us, and the influence this form has on the way the genetic material is expressed. The results have among others led to new methods of analysis and contributed to new therapeutic insights in the fight against cancer.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • van Schooten, Frederik, Supervisor
  • Evelo, Chris, Co-Supervisor
Award date21 Jun 2012
Place of Publication's-Hertogenbosch
Publication statusPublished - 1 Jan 2012


  • bioinformatics
  • epigenetics
  • microarray
  • equencing technology

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