Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals

M.S. de Abreu*, K.A. Demin, A.C.V.V. Giacomini, T.G. Amstislavskaya, T. Strekalova, G.O. Maslov, Y. Kositsin, E.V. Petersen, A.V. Kalueff*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition to well-established physiological cascades, stress also evokes various brain and behavioral responses. Aquatic animal models, including the zebrafish (Danio rerio), have been extensively used to probe pathobiological mechanisms of stress and stress-related brain disorders. Here, we critically discuss the use of zebrafish models for studying mechanisms of stress and modeling its disorders experimentally, with a particular cross-taxon focus on the potential evolution of stress responses from zebrafish to rodents and humans, as well as its translational implications.
Original languageEnglish
Article number100405
Number of pages11
JournalNeurobiology of Stress
Volume15
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • Zebrafish
  • Rodents
  • Cortisol
  • Stress axis
  • Behavior
  • Animal models
  • TROUT ONCORHYNCHUS-MYKISS
  • TANDEM MASS-SPECTROMETRY
  • REPEATED SOCIAL DEFEAT
  • ACUTE RESTRAINT STRESS
  • WHOLE-BODY CORTISOL
  • SEX-DIFFERENCES
  • PREFRONTAL CORTEX
  • NEUROTROPHIC FACTOR
  • DANIO-RERIO
  • PSYCHOLOGICAL STRESS

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