Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models

M.S. de Abreu; A.C.V.V. Giacomini; R. Genario; K.A. Demin; T.G. Amstislavskaya; F. Costa; D.B. Rosemberg; L.U. Sneddon; T. Strekalova; M.C. Soares; A.V. Kalueff

doi:10.1016/j.neulet.2021.136382

Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models

M.S. de Abreu^*
, A.C.V.V. Giacomini
, R. Genario
, K.A. Demin
, T.G. Amstislavskaya
, F. Costa
, D.B. Rosemberg
, L.U. Sneddon
, T. Strekalova
, M.C. Soares
, A.V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Critical for organismal survival, pain evokes strong physiological and behavioral responses in various sentient species. Clinical and preclinical (animal) studies markedly increase our understanding of biological consequences of developmental (early-life) adversity, as well as acute and chronic pain. However, the long-term effects of early-life pain exposure on human and animal emotional responses remain poorly understood. Here, we discuss experimental models of nociception in rodents and zebrafish, and summarize mounting evidence of the role of early-life pain in shaping emotional traits later in life. We also call for further development of animal models to probe the impact of early-life pain exposure on behavioral traits, brain disorders and novel therapeutic treatments.

Original language	English
Article number	136382
Number of pages	7
Journal	Neuroscience Letters
Volume	768
DOIs	https://doi.org/10.1016/j.neulet.2021.136382
Publication status	Published - 18 Jan 2022

Keywords

Pain
Animal models
Emotional response
Behavior
Early-life exposure
CORTICOTROPIN-RELEASING-FACTOR
LOW-BIRTH-WEIGHT
BEHAVIORAL-MODEL
CHILDREN BORN
NEONATAL PAIN
INTERNALIZING BEHAVIORS
CORTISOL-LEVELS
RISK-FACTOR
STRESS
EXPOSURE

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de Abreu, M. S., Giacomini, A. C. V. V., Genario, R., Demin, K. A., Amstislavskaya, T. G., Costa, F., Rosemberg, D. B., Sneddon, L. U., Strekalova, T., Soares, M. C., & Kalueff, A. V. (2022). Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models. Neuroscience Letters, 768, Article 136382. https://doi.org/10.1016/j.neulet.2021.136382

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title = "Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models",

abstract = "Critical for organismal survival, pain evokes strong physiological and behavioral responses in various sentient species. Clinical and preclinical (animal) studies markedly increase our understanding of biological consequences of developmental (early-life) adversity, as well as acute and chronic pain. However, the long-term effects of early-life pain exposure on human and animal emotional responses remain poorly understood. Here, we discuss experimental models of nociception in rodents and zebrafish, and summarize mounting evidence of the role of early-life pain in shaping emotional traits later in life. We also call for further development of animal models to probe the impact of early-life pain exposure on behavioral traits, brain disorders and novel therapeutic treatments.",

keywords = "Pain, Animal models, Emotional response, Behavior, Early-life exposure, CORTICOTROPIN-RELEASING-FACTOR, LOW-BIRTH-WEIGHT, BEHAVIORAL-MODEL, CHILDREN BORN, NEONATAL PAIN, INTERNALIZING BEHAVIORS, CORTISOL-LEVELS, RISK-FACTOR, STRESS, EXPOSURE",

author = "\{de Abreu\}, M.S. and A.C.V.V. Giacomini and R. Genario and K.A. Demin and T.G. Amstislavskaya and F. Costa and D.B. Rosemberg and L.U. Sneddon and T. Strekalova and M.C. Soares and A.V. Kalueff",

note = "Funding Information: AVK is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China). He chairs the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory project. KAD is supported by the budgetary funds to St. Petersburg State University (project 73026081). ACVVG is supported by the FAPERGS research fellowships 19/2551-0001-669-7. TGA is supported by the Russian Science Foundation (RSF) grant 20-65-46006. MCS was supported by Portuguese National Funds through FCT (DL57/2016/CP1440/CT0019). The study used the facilities and equipment of the Resource Fund of Applied Genetics MIPT, Russia (support grant 075-15-2021-684). FC and KAD are supported by Sirius University of Science and Technology (Sochi, Russia). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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month = jan,

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doi = "10.1016/j.neulet.2021.136382",

language = "English",

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de Abreu, MS, Giacomini, ACVV, Genario, R, Demin, KA, Amstislavskaya, TG, Costa, F, Rosemberg, DB, Sneddon, LU, Strekalova, T, Soares, MC & Kalueff, AV 2022, 'Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models', Neuroscience Letters, vol. 768, 136382. https://doi.org/10.1016/j.neulet.2021.136382

TY - JOUR

T1 - Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models

AU - de Abreu, M.S.

AU - Giacomini, A.C.V.V.

AU - Genario, R.

AU - Demin, K.A.

AU - Amstislavskaya, T.G.

AU - Costa, F.

AU - Rosemberg, D.B.

AU - Sneddon, L.U.

AU - Strekalova, T.

AU - Soares, M.C.

AU - Kalueff, A.V.

N1 - Funding Information: AVK is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China). He chairs the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory project. KAD is supported by the budgetary funds to St. Petersburg State University (project 73026081). ACVVG is supported by the FAPERGS research fellowships 19/2551-0001-669-7. TGA is supported by the Russian Science Foundation (RSF) grant 20-65-46006. MCS was supported by Portuguese National Funds through FCT (DL57/2016/CP1440/CT0019). The study used the facilities and equipment of the Resource Fund of Applied Genetics MIPT, Russia (support grant 075-15-2021-684). FC and KAD are supported by Sirius University of Science and Technology (Sochi, Russia). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/1/18

Y1 - 2022/1/18

N2 - Critical for organismal survival, pain evokes strong physiological and behavioral responses in various sentient species. Clinical and preclinical (animal) studies markedly increase our understanding of biological consequences of developmental (early-life) adversity, as well as acute and chronic pain. However, the long-term effects of early-life pain exposure on human and animal emotional responses remain poorly understood. Here, we discuss experimental models of nociception in rodents and zebrafish, and summarize mounting evidence of the role of early-life pain in shaping emotional traits later in life. We also call for further development of animal models to probe the impact of early-life pain exposure on behavioral traits, brain disorders and novel therapeutic treatments.

AB - Critical for organismal survival, pain evokes strong physiological and behavioral responses in various sentient species. Clinical and preclinical (animal) studies markedly increase our understanding of biological consequences of developmental (early-life) adversity, as well as acute and chronic pain. However, the long-term effects of early-life pain exposure on human and animal emotional responses remain poorly understood. Here, we discuss experimental models of nociception in rodents and zebrafish, and summarize mounting evidence of the role of early-life pain in shaping emotional traits later in life. We also call for further development of animal models to probe the impact of early-life pain exposure on behavioral traits, brain disorders and novel therapeutic treatments.

KW - Pain

KW - Animal models

KW - Emotional response

KW - Behavior

KW - Early-life exposure

KW - CORTICOTROPIN-RELEASING-FACTOR

KW - LOW-BIRTH-WEIGHT

KW - BEHAVIORAL-MODEL

KW - CHILDREN BORN

KW - NEONATAL PAIN

KW - INTERNALIZING BEHAVIORS

KW - CORTISOL-LEVELS

KW - RISK-FACTOR

KW - STRESS

KW - EXPOSURE

U2 - 10.1016/j.neulet.2021.136382

DO - 10.1016/j.neulet.2021.136382

M3 - Article

C2 - 34861343

SN - 0304-3940

VL - 768

JO - Neuroscience Letters

JF - Neuroscience Letters

M1 - 136382

ER -

Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models

Abstract

Keywords

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