Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Mitchell J. Geer, Johanna P. van Geffen, Piraveen Gopalasingam, Timo Vogtle, Christopher W. Smith, Silke Heising, Marijke J. E. Kuijpers, Bibian M. E. Tullemans, Gavin E. Jarvis, Johannes A. Eble, Mark Jeeves, Michael Overduin, Johan W. M. Heemskerk, Alexandra Mazharian, Yotis A. Senis

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1413-1425
Number of pages13
JournalBlood
Volume132
Issue number13
DOIs
Publication statusPublished - 27 Sep 2018

Keywords

  • ACTIVATION
  • PROTEIN
  • THROMBOCYTOPENIA
  • PHOSPHORYLATION
  • MICE

Cite this

Geer, M. J., van Geffen, J. P., Gopalasingam, P., Vogtle, T., Smith, C. W., Heising, S., Kuijpers, M. J. E., Tullemans, B. M. E., Jarvis, G. E., Eble, J. A., Jeeves, M., Overduin, M., Heemskerk, J. W. M., Mazharian, A., & Senis, Y. A. (2018). Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis. Blood, 132(13), 1413-1425. https://doi.org/10.1182/blood-2017-10-802975