Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Mitchell J. Geer; Johanna P. van Geffen; Piraveen Gopalasingam; Timo Vogtle; Christopher W. Smith; Silke Heising; Marijke J. E. Kuijpers; Bibian M. E. Tullemans; Gavin E. Jarvis; Johannes A. Eble; Mark Jeeves; Michael Overduin; Johan W. M. Heemskerk; Alexandra Mazharian; Yotis A. Senis

doi:10.1182/blood-2017-10-802975

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Mitchell J. Geer, Johanna P. van Geffen, Piraveen Gopalasingam, Timo Vogtle, Christopher W. Smith, Silke Heising, Marijke J. E. Kuijpers, Bibian M. E. Tullemans, Gavin E. Jarvis, Johannes A. Eble, Mark Jeeves, Michael Overduin, Johan W. M. Heemskerk, Alexandra Mazharian, Yotis A. Senis

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1413-1425
Number of pages	13
Journal	Blood
Volume	132
Issue number	13
DOIs	https://doi.org/10.1182/blood-2017-10-802975
Publication status	Published - 27 Sep 2018

Keywords

ACTIVATION
PROTEIN
THROMBOCYTOPENIA
PHOSPHORYLATION
MICE

Access to Document

10.1182/blood-2017-10-802975

Cite this

Geer, M. J., van Geffen, J. P., Gopalasingam, P., Vogtle, T., Smith, C. W., Heising, S., Kuijpers, M. J. E., Tullemans, B. M. E., Jarvis, G. E., Eble, J. A., Jeeves, M., Overduin, M., Heemskerk, J. W. M., Mazharian, A., & Senis, Y. A. (2018). Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis. Blood, 132(13), 1413-1425. https://doi.org/10.1182/blood-2017-10-802975

Geer, Mitchell J. ; van Geffen, Johanna P. ; Gopalasingam, Piraveen ; Vogtle, Timo ; Smith, Christopher W. ; Heising, Silke ; Kuijpers, Marijke J. E. ; Tullemans, Bibian M. E. ; Jarvis, Gavin E. ; Eble, Johannes A. ; Jeeves, Mark ; Overduin, Michael ; Heemskerk, Johan W. M. ; Mazharian, Alexandra ; Senis, Yotis A. / Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis. In: Blood. 2018 ; Vol. 132, No. 13. pp. 1413-1425.

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title = "Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis",

keywords = "ACTIVATION, PROTEIN, THROMBOCYTOPENIA, PHOSPHORYLATION, MICE",

author = "Geer, {Mitchell J.} and {van Geffen}, {Johanna P.} and Piraveen Gopalasingam and Timo Vogtle and Smith, {Christopher W.} and Silke Heising and Kuijpers, {Marijke J. E.} and Tullemans, {Bibian M. E.} and Jarvis, {Gavin E.} and Eble, {Johannes A.} and Mark Jeeves and Michael Overduin and Heemskerk, {Johan W. M.} and Alexandra Mazharian and Senis, {Yotis A.}",

year = "2018",

month = sep,

day = "27",

doi = "10.1182/blood-2017-10-802975",

language = "English",

volume = "132",

pages = "1413--1425",

journal = "Blood",

issn = "0006-4971",

publisher = "The American Society of Hematology",

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Geer, MJ, van Geffen, JP, Gopalasingam, P, Vogtle, T, Smith, CW, Heising, S, Kuijpers, MJE , Tullemans, BME, Jarvis, GE, Eble, JA, Jeeves, M, Overduin, M, Heemskerk, JWM, Mazharian, A & Senis, YA 2018, 'Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis', Blood, vol. 132, no. 13, pp. 1413-1425. https://doi.org/10.1182/blood-2017-10-802975

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis. / Geer, Mitchell J.; van Geffen, Johanna P.; Gopalasingam, Piraveen; Vogtle, Timo; Smith, Christopher W.; Heising, Silke; Kuijpers, Marijke J. E.; Tullemans, Bibian M. E.; Jarvis, Gavin E.; Eble, Johannes A.; Jeeves, Mark; Overduin, Michael; Heemskerk, Johan W. M.; Mazharian, Alexandra; Senis, Yotis A.

In: Blood, Vol. 132, No. 13, 27.09.2018, p. 1413-1425.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

AU - Geer, Mitchell J.

AU - van Geffen, Johanna P.

AU - Gopalasingam, Piraveen

AU - Vogtle, Timo

AU - Smith, Christopher W.

AU - Heising, Silke

AU - Kuijpers, Marijke J. E.

AU - Tullemans, Bibian M. E.

AU - Jarvis, Gavin E.

AU - Eble, Johannes A.

AU - Jeeves, Mark

AU - Overduin, Michael

AU - Heemskerk, Johan W. M.

AU - Mazharian, Alexandra

AU - Senis, Yotis A.

PY - 2018/9/27

Y1 - 2018/9/27

KW - ACTIVATION

KW - PROTEIN

KW - THROMBOCYTOPENIA

KW - PHOSPHORYLATION

KW - MICE

U2 - 10.1182/blood-2017-10-802975

DO - 10.1182/blood-2017-10-802975

M3 - Article

VL - 132

SP - 1413

EP - 1425

JO - Blood

JF - Blood

SN - 0006-4971

IS - 13

ER -