Ultrasound-accelerated catheter-directed thrombolysis for the prevention of post-thrombotic syndrome

Pascale Notten

Research output: ThesisDoctoral ThesisInternal

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Approximately 2.5-5.0% of people develop deep vein thrombosis (DVT) during their lifetime, after which 40-60% of patients experience long-term symptoms. This is called post-thrombotic syndrome (PTS). Symptoms can include swollen, painful and tired legs with varicose veins, skin changes, and in the worst case, leg ulcers. PTS negatively affects quality of life and leads to an increased usage of healthcare.
In this dissertation, it is examined whether the development of PTS can be prevented in patients with DVT in the groin area when they are additionally treated with catheter-controlled thrombolysis. A catheter is inserted and positioned at the level of the clot so that medication can be given locally to break up the clot. After the clot has been removed, if necessary, the flow of blood through the blood vessel can be ensured by placing a venous stent. Based on the research results from this dissertation, it is not yet possible to give a definitive answer to the question of whether an additional thrombolysis treatment can prevent the development of PTS. The results tend to have a positive effect, but this will have to be investigated further, including methods to improve patient selection as well as the applied techniques and treatment protocols.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • ten Cate, Hugo, Supervisor
  • Jacobs, Michael, Supervisor
  • Hoek - ten Cate, Arina, Co-Supervisor
Award date26 Nov 2020
Place of PublicationMaastricht
Print ISBNs9789464230215
Publication statusPublished - 2020


  • deep vein thrombosis
  • post thrombotic syndrome
  • venous catheter-controlled thrombolysis
  • venous stenting
  • quality of life
  • anti-thrombotic treatment

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