Ultra-high resolution blood volume fMRI and BOLD fMRI in humans at 9.4 T: Capabilities and challenges

Laurentius Huber, Desmond H Y Tse, Christopher J Wiggins, Kâmil Uludağ, Sriranga Kashyap, David C Jangraw, Peter A Bandettini, Benedikt A Poser, Dimo Ivanov

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Functional mapping of cerebral blood volume (CBV) changes has the potential to reveal brain activity with high localization specificity at the level of cortical layers and columns. Non-invasive CBV imaging using Vascular Space Occupancy (VASO) at ultra-high magnetic field strengths promises high spatial specificity but poses unique challenges in human applications. As such, 9.4 T B1+ and B0 inhomogeneities limit efficient blood tagging, while the specific absorption rate (SAR) constraints limit the application of VASO-specific RF pulses. Moreover, short T2* values at 9.4 T require short readout duration, and long T1 values at 9.4 T can cause blood-inflow contaminations. In this study, we investigated the applicability of layer-dependent CBV-fMRI at 9.4 T in humans. We addressed the aforementioned challenges by combining multiple technical advancements: temporally alternating pTx B1+ shimming parameters, advanced adiabatic RF-pulses, 3D-EPI signal readout, optimized GRAPPA acquisition and reconstruction, and stability-optimized RF channel combination. We found that a combination of suitable advanced methodology alleviates the challenges and potential artifacts, and that VASO fMRI provides reliable measures of CBV change across cortical layers in humans at 9.4 T. The localization specificity of CBV-fMRI, combined with the high sensitivity of 9.4 T, makes this method an important tool for future studies investigating cortical micro-circuitry in humans.

Original languageEnglish
Pages (from-to)769-779
Number of pages11
JournalNeuroimage
Volume178
DOIs
Publication statusPublished - Sep 2018

Keywords

  • Journal Article

Cite this

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title = "Ultra-high resolution blood volume fMRI and BOLD fMRI in humans at 9.4 T: Capabilities and challenges",
abstract = "Functional mapping of cerebral blood volume (CBV) changes has the potential to reveal brain activity with high localization specificity at the level of cortical layers and columns. Non-invasive CBV imaging using Vascular Space Occupancy (VASO) at ultra-high magnetic field strengths promises high spatial specificity but poses unique challenges in human applications. As such, 9.4 T B1+ and B0 inhomogeneities limit efficient blood tagging, while the specific absorption rate (SAR) constraints limit the application of VASO-specific RF pulses. Moreover, short T2* values at 9.4 T require short readout duration, and long T1 values at 9.4 T can cause blood-inflow contaminations. In this study, we investigated the applicability of layer-dependent CBV-fMRI at 9.4 T in humans. We addressed the aforementioned challenges by combining multiple technical advancements: temporally alternating pTx B1+ shimming parameters, advanced adiabatic RF-pulses, 3D-EPI signal readout, optimized GRAPPA acquisition and reconstruction, and stability-optimized RF channel combination. We found that a combination of suitable advanced methodology alleviates the challenges and potential artifacts, and that VASO fMRI provides reliable measures of CBV change across cortical layers in humans at 9.4 T. The localization specificity of CBV-fMRI, combined with the high sensitivity of 9.4 T, makes this method an important tool for future studies investigating cortical micro-circuitry in humans.",
keywords = "Journal Article",
author = "Laurentius Huber and Tse, {Desmond H Y} and Wiggins, {Christopher J} and K{\^a}mil Uludağ and Sriranga Kashyap and Jangraw, {David C} and Bandettini, {Peter A} and Poser, {Benedikt A} and Dimo Ivanov",
note = "Copyright {\circledC} 2018. Published by Elsevier Inc.",
year = "2018",
month = "9",
doi = "10.1016/j.neuroimage.2018.06.025",
language = "English",
volume = "178",
pages = "769--779",
journal = "Neuroimage",
issn = "1053-8119",
publisher = "Elsevier Science",

}

Ultra-high resolution blood volume fMRI and BOLD fMRI in humans at 9.4 T : Capabilities and challenges. / Huber, Laurentius; Tse, Desmond H Y; Wiggins, Christopher J; Uludağ, Kâmil; Kashyap, Sriranga; Jangraw, David C; Bandettini, Peter A; Poser, Benedikt A; Ivanov, Dimo.

In: Neuroimage, Vol. 178, 09.2018, p. 769-779.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Ultra-high resolution blood volume fMRI and BOLD fMRI in humans at 9.4 T

T2 - Capabilities and challenges

AU - Huber, Laurentius

AU - Tse, Desmond H Y

AU - Wiggins, Christopher J

AU - Uludağ, Kâmil

AU - Kashyap, Sriranga

AU - Jangraw, David C

AU - Bandettini, Peter A

AU - Poser, Benedikt A

AU - Ivanov, Dimo

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018/9

Y1 - 2018/9

N2 - Functional mapping of cerebral blood volume (CBV) changes has the potential to reveal brain activity with high localization specificity at the level of cortical layers and columns. Non-invasive CBV imaging using Vascular Space Occupancy (VASO) at ultra-high magnetic field strengths promises high spatial specificity but poses unique challenges in human applications. As such, 9.4 T B1+ and B0 inhomogeneities limit efficient blood tagging, while the specific absorption rate (SAR) constraints limit the application of VASO-specific RF pulses. Moreover, short T2* values at 9.4 T require short readout duration, and long T1 values at 9.4 T can cause blood-inflow contaminations. In this study, we investigated the applicability of layer-dependent CBV-fMRI at 9.4 T in humans. We addressed the aforementioned challenges by combining multiple technical advancements: temporally alternating pTx B1+ shimming parameters, advanced adiabatic RF-pulses, 3D-EPI signal readout, optimized GRAPPA acquisition and reconstruction, and stability-optimized RF channel combination. We found that a combination of suitable advanced methodology alleviates the challenges and potential artifacts, and that VASO fMRI provides reliable measures of CBV change across cortical layers in humans at 9.4 T. The localization specificity of CBV-fMRI, combined with the high sensitivity of 9.4 T, makes this method an important tool for future studies investigating cortical micro-circuitry in humans.

AB - Functional mapping of cerebral blood volume (CBV) changes has the potential to reveal brain activity with high localization specificity at the level of cortical layers and columns. Non-invasive CBV imaging using Vascular Space Occupancy (VASO) at ultra-high magnetic field strengths promises high spatial specificity but poses unique challenges in human applications. As such, 9.4 T B1+ and B0 inhomogeneities limit efficient blood tagging, while the specific absorption rate (SAR) constraints limit the application of VASO-specific RF pulses. Moreover, short T2* values at 9.4 T require short readout duration, and long T1 values at 9.4 T can cause blood-inflow contaminations. In this study, we investigated the applicability of layer-dependent CBV-fMRI at 9.4 T in humans. We addressed the aforementioned challenges by combining multiple technical advancements: temporally alternating pTx B1+ shimming parameters, advanced adiabatic RF-pulses, 3D-EPI signal readout, optimized GRAPPA acquisition and reconstruction, and stability-optimized RF channel combination. We found that a combination of suitable advanced methodology alleviates the challenges and potential artifacts, and that VASO fMRI provides reliable measures of CBV change across cortical layers in humans at 9.4 T. The localization specificity of CBV-fMRI, combined with the high sensitivity of 9.4 T, makes this method an important tool for future studies investigating cortical micro-circuitry in humans.

KW - Journal Article

U2 - 10.1016/j.neuroimage.2018.06.025

DO - 10.1016/j.neuroimage.2018.06.025

M3 - Article

C2 - 29890330

VL - 178

SP - 769

EP - 779

JO - Neuroimage

JF - Neuroimage

SN - 1053-8119

ER -