Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).

C. Bosetti, E. Lucenteforte, P.M. Bracci, E. Negri, R.E. Neale, H.A. Risch, S.H. Olson, S. Gallinger, A.B. Miller, H.B. Bueno-de-Mesquita, R. Talamini, J. Polesel, P. Ghadirian, P.A. Baghurst, W. Zatonski, E. Fontham, E.A. Holly, Y.T. Gao, H. Yu, R.C. KurtzM. Cotterchio, P. Maisonneuve, M.P. Zeegers, E.J. Duell, P. Boffetta, C. La Vecchia

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Abstract

BACKGROUND: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. METHODS: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. RESULTS: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. CONCLUSIONS: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.
Original languageEnglish
Pages (from-to)2903-2910
JournalAnnals of Oncology
Volume24
Issue number11
DOIs
Publication statusPublished - 1 Jan 2013

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Bosetti, C., Lucenteforte, E., Bracci, P. M., Negri, E., Neale, R. E., Risch, H. A., Olson, S. H., Gallinger, S., Miller, A. B., Bueno-de-Mesquita, H. B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P. A., Zatonski, W., Fontham, E., Holly, E. A., Gao, Y. T., Yu, H., ... La Vecchia, C. (2013). Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). Annals of Oncology, 24(11), 2903-2910. https://doi.org/10.1093/annonc/mdt336