UCP3 in muscle wasting, a role in modulating lipotoxicity?

R. Minnaard, P. Schrauwen, G. Schaart, M.K. Hesselink*

*Corresponding author for this work

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UCP3 has been postulated to function in the defense against lipid-induced oxidative muscle damage (lipotoxicity). We explored this hypothesis during cachexia in rats (zymosan-induced sepsis), a condition characterized by increased oxidative stress and supply of fatty acids to the muscle. Muscle UCP3 protein content was increased 2, 6 and 11 days after zymosan injection. Plasma FFA levels were increased at day 2, but dropped below control levels on days 6 and 11. Muscular levels of the lipid peroxidation byproduct 4-hydroxy-2-nonenal (4-HNE) were increased at days 6 and 11 in zymosan-treated rats, supporting a role for UCP3 in modulating lipotoxicity during cachexia
Original languageEnglish
Pages (from-to)5172-5176
JournalFebs Letters
Issue number22
Publication statusPublished - 1 Jan 2006

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