Type I and II Endometrial Cancers: Have They Different Risk Factors?

Veronica Wendy Setiawan; Hannah P. Yang; Malcolm C. Pike; Susan E. McCann; Herbert Yu; Yong-Bing Xiang; Alicja Wolk; Nicolas Wentzensen; Noel S. Weiss; Penelope M. Webb; Piet A. van den Brandt; Koen van de Vijver; Pamela J. Thompson; Brian L. Strom; Amanda B. Spurdle; Robert A. Soslow; Xiao-Ou Shu; Catherine Schairer; Carlotta Sacerdote; Thomas E. Rohan; Kim Robien; Harvey A. Risch; Fulvio Ricceri; Timothy R. Rebbeck; Radhai Rastogi; Jennifer Prescott; Silvia Polidoro; Yikyung Park; Sara H. Olson; Kirsten B. Moysich; Anthony B. Miller; Marjorie L. McCullough; Rayna K. Matsuno; Anthony M. Magliocco; Galina Lurie; Lingeng Lu; Jolanta Lissowska; Xiaolin Liang; James V., Jr. Lacey; Laurence N. Kolonel; Brian E. Henderson; Susan E. Hankinson; Niclas Hakansson; Marc T. Goodman; Mia M. Gaudet; Montserrat Garcia-Closas; Christine M. Friedenreich; Jo L. Freudenheim; Jennifer A. Doherty; Immaculata De Vivo; Kerry S. Courneya; Linda S. Cook; Chu Chen; James R. Cerhan; Hui Cai; Louise A. Brinton; Leslie Bernstein; Kristin E. Anderson; Hoda Anton-Culver; Leo J. Schouten; Pamela L. Horn-Ross

doi:10.1200/JCO.2012.48.2596

Type I and II Endometrial Cancers: Have They Different Risk Factors?

Veronica Wendy Setiawan^*, Hannah P. Yang, Malcolm C. Pike, Susan E. McCann, Herbert Yu, Yong-Bing Xiang, Alicja Wolk, Nicolas Wentzensen, Noel S. Weiss, Penelope M. Webb, Piet A. van den Brandt, Koen van de Vijver, Pamela J. Thompson, Brian L. Strom, Amanda B. Spurdle, Robert A. Soslow, Xiao-Ou Shu, Catherine Schairer, Carlotta Sacerdote, Thomas E. RohanKim Robien, Harvey A. Risch, Fulvio Ricceri, Timothy R. Rebbeck, Radhai Rastogi, Jennifer Prescott, Silvia Polidoro, Yikyung Park, Sara H. Olson, Kirsten B. Moysich, Anthony B. Miller, Marjorie L. McCullough, Rayna K. Matsuno, Anthony M. Magliocco, Galina Lurie, Lingeng Lu, Jolanta Lissowska, Xiaolin Liang, James V., Jr. Lacey, Laurence N. Kolonel, Brian E. Henderson, Susan E. Hankinson, Niclas Hakansson, Marc T. Goodman, Mia M. Gaudet, Montserrat Garcia-Closas, Christine M. Friedenreich, Jo L. Freudenheim, Jennifer A. Doherty, Immaculata De Vivo, Kerry S. Courneya, Linda S. Cook, Chu Chen, James R. Cerhan, Hui Cai, Louise A. Brinton, Leslie Bernstein, Kristin E. Anderson, Hoda Anton-Culver, Leo J. Schouten, Pamela L. Horn-Ross

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors. Patients and Methods Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors. Results Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m(2) increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P-heterogeneity <.0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar. Conclusion The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed.

Original language	English
Pages (from-to)	2607-2618
Journal	Journal of Clinical Oncology
Volume	31
Issue number	20
DOIs	https://doi.org/10.1200/JCO.2012.48.2596
Publication status	Published - 10 Jul 2013

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10.1200/JCO.2012.48.2596

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Setiawan, V. W., Yang, H. P., Pike, M. C., McCann, S. E., Yu, H., Xiang, Y.-B., Wolk, A., Wentzensen, N., Weiss, N. S., Webb, P. M., van den Brandt, P. A., van de Vijver, K., Thompson, P. J., Strom, B. L., Spurdle, A. B., Soslow, R. A., Shu, X.-O., Schairer, C., Sacerdote, C., ... Horn-Ross, P. L. (2013). Type I and II Endometrial Cancers: Have They Different Risk Factors? Journal of Clinical Oncology, 31(20), 2607-2618. https://doi.org/10.1200/JCO.2012.48.2596

@article{9f69130a75914fa784425810e54aa3c7,

title = "Type I and II Endometrial Cancers: Have They Different Risk Factors?",

abstract = "Purpose Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors. Patients and Methods Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors. Results Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m(2) increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P-heterogeneity <.0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar. Conclusion The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed. ",

author = "Setiawan, {Veronica Wendy} and Yang, {Hannah P.} and Pike, {Malcolm C.} and McCann, {Susan E.} and Herbert Yu and Yong-Bing Xiang and Alicja Wolk and Nicolas Wentzensen and Weiss, {Noel S.} and Webb, {Penelope M.} and {van den Brandt}, {Piet A.} and {van de Vijver}, Koen and Thompson, {Pamela J.} and Strom, {Brian L.} and Spurdle, {Amanda B.} and Soslow, {Robert A.} and Xiao-Ou Shu and Catherine Schairer and Carlotta Sacerdote and Rohan, {Thomas E.} and Kim Robien and Risch, {Harvey A.} and Fulvio Ricceri and Rebbeck, {Timothy R.} and Radhai Rastogi and Jennifer Prescott and Silvia Polidoro and Yikyung Park and Olson, {Sara H.} and Moysich, {Kirsten B.} and Miller, {Anthony B.} and McCullough, {Marjorie L.} and Matsuno, {Rayna K.} and Magliocco, {Anthony M.} and Galina Lurie and Lingeng Lu and Jolanta Lissowska and Xiaolin Liang and Lacey, {James V., Jr.} and Kolonel, {Laurence N.} and Henderson, {Brian E.} and Hankinson, {Susan E.} and Niclas Hakansson and Goodman, {Marc T.} and Gaudet, {Mia M.} and Montserrat Garcia-Closas and Friedenreich, {Christine M.} and Freudenheim, {Jo L.} and Doherty, {Jennifer A.} and {De Vivo}, Immaculata and Courneya, {Kerry S.} and Cook, {Linda S.} and Chu Chen and Cerhan, {James R.} and Hui Cai and Brinton, {Louise A.} and Leslie Bernstein and Anderson, {Kristin E.} and Hoda Anton-Culver and Schouten, {Leo J.} and Horn-Ross, {Pamela L.}",

year = "2013",

month = jul,

day = "10",

doi = "10.1200/JCO.2012.48.2596",

language = "English",

volume = "31",

pages = "2607--2618",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "American Society of Clinical Oncology",

number = "20",

}

Setiawan, VW, Yang, HP, Pike, MC, McCann, SE, Yu, H, Xiang, Y-B, Wolk, A, Wentzensen, N, Weiss, NS, Webb, PM, van den Brandt, PA, van de Vijver, K, Thompson, PJ, Strom, BL, Spurdle, AB, Soslow, RA, Shu, X-O, Schairer, C, Sacerdote, C, Rohan, TE, Robien, K, Risch, HA, Ricceri, F, Rebbeck, TR, Rastogi, R, Prescott, J, Polidoro, S, Park, Y, Olson, SH, Moysich, KB, Miller, AB, McCullough, ML, Matsuno, RK, Magliocco, AM, Lurie, G, Lu, L, Lissowska, J, Liang, X, Lacey, JVJ, Kolonel, LN, Henderson, BE, Hankinson, SE, Hakansson, N, Goodman, MT, Gaudet, MM, Garcia-Closas, M, Friedenreich, CM, Freudenheim, JL, Doherty, JA, De Vivo, I, Courneya, KS, Cook, LS, Chen, C, Cerhan, JR, Cai, H, Brinton, LA, Bernstein, L, Anderson, KE, Anton-Culver, H, Schouten, LJ & Horn-Ross, PL 2013, 'Type I and II Endometrial Cancers: Have They Different Risk Factors?', Journal of Clinical Oncology, vol. 31, no. 20, pp. 2607-2618. https://doi.org/10.1200/JCO.2012.48.2596