Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study

Roberto Lorusso*, Sandro Gelsomino, Fabiana Luca, Giuseppe De Cicco, Giuseppe Bille, Rocco Carella, Emanuel Villa, Gianni Troise, Mario Vigano, Carlo Banfi, Carmine Gazzaruso, Pier Gagliardotto, Lorenzo Menicanti, Francesco Formica, Giovanni Paolini, Stefano Benussi, Ottavio Alfieri, Matteo Pastore, Sandro Ferrarese, Giovanni MariscalcoGermano Di Credico, Cristian Leva, Claudio Russo, Aldo Cannata, Roberto Trevisan, Ugolino Livi, Roberto Scrofani, Carlo Antona, Andrea Sala, Gian Franco Gensini, Jos Maessen, Andrea Giustina

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background-The present study was aimed at determining the impact of type 2 diabetes mellitus (DM) on postoperative bioprosthetic structural valve degeneration. Methods and Results-Twelve Italian centers participated in the study. Patient data refer to bioprosthetic implantations performed from November 1988 to December 2009, which resulted in 6184 patients (mean age 71.3+/-5.4 years, 60.1% male) being enrolled. Of these patients, 1731 (27.9%) had type 2 DM. The propensity score-matching algorithm successfully matched 1113 patients with type 2 DM with the same number of no-DM patients. The postmatching standard differences were less than 0.1 for each of the covariates, and 64.2% of DM patients were matched. The early (30 days) mortality rate was 7.8% (n=87) versus 2.9% (n=33) in patients with or without type 2 DM (P
Original languageEnglish
Pages (from-to)604-614
Issue number4
Publication statusPublished - 31 Jan 2012


  • heart valve surgery
  • prosthetic heart valves
  • type 2 diabetes mellitus

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