Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study

Roberto Lorusso; Sandro Gelsomino; Fabiana Luca; Giuseppe De Cicco; Giuseppe Bille; Rocco Carella; Emanuel Villa; Gianni Troise; Mario Vigano; Carlo Banfi; Carmine Gazzaruso; Pier Gagliardotto; Lorenzo Menicanti; Francesco Formica; Giovanni Paolini; Stefano Benussi; Ottavio Alfieri; Matteo Pastore; Sandro Ferrarese; Giovanni Mariscalco; Germano Di Credico; Cristian Leva; Claudio Russo; Aldo Cannata; Roberto Trevisan; Ugolino Livi; Roberto Scrofani; Carlo Antona; Andrea Sala; Gian Franco Gensini; Jos Maessen; Andrea Giustina

doi:10.1161/CIRCULATIONAHA.111.025064

Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study

Roberto Lorusso^*, Sandro Gelsomino, Fabiana Luca, Giuseppe De Cicco, Giuseppe Bille, Rocco Carella, Emanuel Villa, Gianni Troise, Mario Vigano, Carlo Banfi, Carmine Gazzaruso, Pier Gagliardotto, Lorenzo Menicanti, Francesco Formica, Giovanni Paolini, Stefano Benussi, Ottavio Alfieri, Matteo Pastore, Sandro Ferrarese, Giovanni MariscalcoGermano Di Credico, Cristian Leva, Claudio Russo, Aldo Cannata, Roberto Trevisan, Ugolino Livi, Roberto Scrofani, Carlo Antona, Andrea Sala, Gian Franco Gensini, Jos Maessen, Andrea Giustina

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background-The present study was aimed at determining the impact of type 2 diabetes mellitus (DM) on postoperative bioprosthetic structural valve degeneration. Methods and Results-Twelve Italian centers participated in the study. Patient data refer to bioprosthetic implantations performed from November 1988 to December 2009, which resulted in 6184 patients (mean age 71.3+/-5.4 years, 60.1% male) being enrolled. Of these patients, 1731 (27.9%) had type 2 DM. The propensity score-matching algorithm successfully matched 1113 patients with type 2 DM with the same number of no-DM patients. The postmatching standard differences were less than 0.1 for each of the covariates, and 64.2% of DM patients were matched. The early (30 days) mortality rate was 7.8% (n=87) versus 2.9% (n=33) in patients with or without type 2 DM (P

Original language	English
Pages (from-to)	604-614
Journal	Circulation
Volume	125
Issue number	4
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.111.025064
Publication status	Published - 31 Jan 2012

Keywords

heart valve surgery
prosthetic heart valves
type 2 diabetes mellitus

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Lorusso, R., Gelsomino, S., Luca, F., De Cicco, G., Bille, G., Carella, R., Villa, E., Troise, G., Vigano, M., Banfi, C., Gazzaruso, C., Gagliardotto, P., Menicanti, L., Formica, F., Paolini, G., Benussi, S., Alfieri, O., Pastore, M., Ferrarese, S., ... Giustina, A. (2012). Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study. Circulation, 125(4), 604-614. https://doi.org/10.1161/CIRCULATIONAHA.111.025064

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title = "Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study",

abstract = "Background-The present study was aimed at determining the impact of type 2 diabetes mellitus (DM) on postoperative bioprosthetic structural valve degeneration. Methods and Results-Twelve Italian centers participated in the study. Patient data refer to bioprosthetic implantations performed from November 1988 to December 2009, which resulted in 6184 patients (mean age 71.3+/-5.4 years, 60.1% male) being enrolled. Of these patients, 1731 (27.9%) had type 2 DM. The propensity score-matching algorithm successfully matched 1113 patients with type 2 DM with the same number of no-DM patients. The postmatching standard differences were less than 0.1 for each of the covariates, and 64.2% of DM patients were matched. The early (30 days) mortality rate was 7.8% (n=87) versus 2.9% (n=33) in patients with or without type 2 DM (P",

keywords = "heart valve surgery, prosthetic heart valves, type 2 diabetes mellitus",

author = "Roberto Lorusso and Sandro Gelsomino and Fabiana Luca and {De Cicco}, Giuseppe and Giuseppe Bille and Rocco Carella and Emanuel Villa and Gianni Troise and Mario Vigano and Carlo Banfi and Carmine Gazzaruso and Pier Gagliardotto and Lorenzo Menicanti and Francesco Formica and Giovanni Paolini and Stefano Benussi and Ottavio Alfieri and Matteo Pastore and Sandro Ferrarese and Giovanni Mariscalco and {Di Credico}, Germano and Cristian Leva and Claudio Russo and Aldo Cannata and Roberto Trevisan and Ugolino Livi and Roberto Scrofani and Carlo Antona and Andrea Sala and Gensini, {Gian Franco} and Jos Maessen and Andrea Giustina",

year = "2012",

month = jan,

day = "31",

doi = "10.1161/CIRCULATIONAHA.111.025064",

language = "English",

volume = "125",

pages = "604--614",

journal = "Circulation",

issn = "0009-7322",

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Lorusso, R , Gelsomino, S, Luca, F, De Cicco, G, Bille, G, Carella, R, Villa, E, Troise, G, Vigano, M, Banfi, C, Gazzaruso, C, Gagliardotto, P, Menicanti, L, Formica, F, Paolini, G, Benussi, S, Alfieri, O, Pastore, M, Ferrarese, S, Mariscalco, G, Di Credico, G, Leva, C, Russo, C, Cannata, A, Trevisan, R, Livi, U, Scrofani, R, Antona, C, Sala, A, Gensini, GF, Maessen, J & Giustina, A 2012, 'Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study', Circulation, vol. 125, no. 4, pp. 604-614. https://doi.org/10.1161/CIRCULATIONAHA.111.025064

TY - JOUR

T1 - Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study

AU - Lorusso, Roberto

AU - Gelsomino, Sandro

AU - Luca, Fabiana

AU - De Cicco, Giuseppe

AU - Bille, Giuseppe

AU - Carella, Rocco

AU - Villa, Emanuel

AU - Troise, Gianni

AU - Vigano, Mario

AU - Banfi, Carlo

AU - Gazzaruso, Carmine

AU - Gagliardotto, Pier

AU - Menicanti, Lorenzo

AU - Formica, Francesco

AU - Paolini, Giovanni

AU - Benussi, Stefano

AU - Alfieri, Ottavio

AU - Pastore, Matteo

AU - Ferrarese, Sandro

AU - Mariscalco, Giovanni

AU - Di Credico, Germano

AU - Leva, Cristian

AU - Russo, Claudio

AU - Cannata, Aldo

AU - Trevisan, Roberto

AU - Livi, Ugolino

AU - Scrofani, Roberto

AU - Antona, Carlo

AU - Sala, Andrea

AU - Gensini, Gian Franco

AU - Maessen, Jos

AU - Giustina, Andrea

PY - 2012/1/31

Y1 - 2012/1/31

N2 - Background-The present study was aimed at determining the impact of type 2 diabetes mellitus (DM) on postoperative bioprosthetic structural valve degeneration. Methods and Results-Twelve Italian centers participated in the study. Patient data refer to bioprosthetic implantations performed from November 1988 to December 2009, which resulted in 6184 patients (mean age 71.3+/-5.4 years, 60.1% male) being enrolled. Of these patients, 1731 (27.9%) had type 2 DM. The propensity score-matching algorithm successfully matched 1113 patients with type 2 DM with the same number of no-DM patients. The postmatching standard differences were less than 0.1 for each of the covariates, and 64.2% of DM patients were matched. The early (30 days) mortality rate was 7.8% (n=87) versus 2.9% (n=33) in patients with or without type 2 DM (P

AB - Background-The present study was aimed at determining the impact of type 2 diabetes mellitus (DM) on postoperative bioprosthetic structural valve degeneration. Methods and Results-Twelve Italian centers participated in the study. Patient data refer to bioprosthetic implantations performed from November 1988 to December 2009, which resulted in 6184 patients (mean age 71.3+/-5.4 years, 60.1% male) being enrolled. Of these patients, 1731 (27.9%) had type 2 DM. The propensity score-matching algorithm successfully matched 1113 patients with type 2 DM with the same number of no-DM patients. The postmatching standard differences were less than 0.1 for each of the covariates, and 64.2% of DM patients were matched. The early (30 days) mortality rate was 7.8% (n=87) versus 2.9% (n=33) in patients with or without type 2 DM (P

KW - heart valve surgery

KW - prosthetic heart valves

KW - type 2 diabetes mellitus

U2 - 10.1161/CIRCULATIONAHA.111.025064

DO - 10.1161/CIRCULATIONAHA.111.025064

M3 - Article

C2 - 22203696

SN - 0009-7322

VL - 125

SP - 604

EP - 614

JO - Circulation

JF - Circulation

IS - 4

ER -

Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve Results From a Propensity Score-Matched Italian Multicenter Study

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Keywords

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