TY - JOUR
T1 - Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques
AU - Scholtes, Vincent P. W.
AU - Peeters, Wouter
AU - van Lammeren, Guus W.
AU - Howard, Dominic P. J.
AU - de Vries, Jean-Paul P. M.
AU - de Borst, Gert Jan
AU - Redgrave, Jessica N.
AU - Kemperman, Hans
AU - Schalkwijk, Casper G.
AU - den Ruijter, Hester M.
AU - de Kleijn, Dominique P. V.
AU - Moll, Frans L.
AU - Rothwell, Peter M.
AU - Pasterkamp, Gerard
PY - 2014/8
Y1 - 2014/8
N2 - Aims: Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results: We used one of the largest biobanks, the Athero-Express study (n = 1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. Conclusion: In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.
AB - Aims: Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. Methods and results: We used one of the largest biobanks, the Athero-Express study (n = 1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. Conclusion: In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.
KW - Carotid endarterectomy
KW - Carotid plaque
KW - Diabetes
KW - Histology
U2 - 10.1016/j.atherosclerosis.2014.05.941
DO - 10.1016/j.atherosclerosis.2014.05.941
M3 - Article
C2 - 24937465
SN - 0021-9150
VL - 235
SP - 418
EP - 423
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -