Twenty-Two-Year Outcome of Cartilage Repair Surgery by Perichondrium Transplantation

Maarten P. F. Janssen*, Esther G. M. van der Linden, Tim A. E. J. Boymans, Tim J. M. Welting, Lodewijk W. van Rhijn, Sjoerd K. Bulstra, Peter J. Emans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)


Objective The main purpose of the present study was to assess the risk for major revision surgery after perichondrium transplantation (PT) at a minimum of 22 years postoperatively and to evaluate the influence of patient characteristics. Design Primary outcome was treatment success or failure. Failure of PT was defined as revision surgery in which the transplant was removed, such as (unicondylar) knee arthroplasty or patellectomy. The functioning of nonfailed patients was evaluated using the International Knee Documentation Committee (IKDC) score. In addition, the influence of patient characteristics was evaluated. Results Ninety knees in 88 patients, aged 16 to 55 years with symptomatic cartilage defects, were treated by PT. Eighty knees in 78 patients were eligible for analysis and 10 patients were lost to follow-up. Twenty-eight knees in 26 patients had undergone major revision surgery. Previous surgery and a longer time of symptoms prior to PT were significantly associated with an increased risk for failure of cartilage repair. Functioning of the remaining 52 patients and influence of patient characteristics was analyzed using their IKDC score. Their median IKDC score was 39.08, but a relatively young age at transplantation was associated with a higher IKDC score. Conclusions This 22-year follow-up study of PT, with objective outcome parameters next to patient-reported outcome measurements in a unique group of patients, shows that overall 66% was without major revision surgery and patient characteristics also influence long-term outcome of cartilage repair surgery.

Original languageEnglish
Article number1947603520958146
Pages (from-to)860S-867S
Number of pages8
Issue number1_SUPPL
Early online date15 Sept 2020
Publication statusPublished - Dec 2021


  • articular cartilage
  • cartilage repair
  • knee
  • cartilage transplantation
  • KNEE
  • AGE

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