Tuning Natural Killer Cell Anti-multiple Myeloma Reactivity by Targeting Inhibitory Signaling via KIR and NKG2A

Niken M. Mahaweni, Femke A. I. Ehlers, Gerard M. J. Bos, Lotte Wieten*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

19 Citations (Web of Science)

Abstract

Natural killer (NK) cells are attractive candidates for allogeneic cell-based immunotherapy due to their potent antitumor effector function and good safety profile. NK cells express killer immunoglobulin-like receptors (KIRs) and the NKG2A receptor important for NK cells education as well as providing inhibitory signals upon encountering HLA-expressing target cells. Multiple myeloma (MM) is an example of a tumor expressing relatively high levels of HLA molecules. In this review, we discuss the functional relevance of inhibitory KIRs and NKG2A for NK cells anti-MM response and strategies to lower these inhibitory signaling to enhance clinical efficacy of allogeneic NK cells in MM.

Original languageEnglish
Article number2848
Number of pages8
JournalFrontiers in Immunology
Volume9
DOIs
Publication statusPublished - 4 Dec 2018

Keywords

  • NK cell
  • NKG2A
  • KIR
  • HLA class I
  • HLA-E
  • multiple myeloma
  • immunotherapy
  • HLA CLASS-I
  • NK CELLS
  • MEDIATED LYSIS
  • CYTOTOXICITY RECEPTORS
  • MISSING SELF
  • PHASE-I
  • TRANSPLANTATION
  • LIGANDS
  • POLYMORPHISM
  • EXPRESSION

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