Abstract
Natural killer (NK) cells are attractive candidates for allogeneic cell-based immunotherapy due to their potent antitumor effector function and good safety profile. NK cells express killer immunoglobulin-like receptors (KIRs) and the NKG2A receptor important for NK cells education as well as providing inhibitory signals upon encountering HLA-expressing target cells. Multiple myeloma (MM) is an example of a tumor expressing relatively high levels of HLA molecules. In this review, we discuss the functional relevance of inhibitory KIRs and NKG2A for NK cells anti-MM response and strategies to lower these inhibitory signaling to enhance clinical efficacy of allogeneic NK cells in MM.
Original language | English |
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Article number | 2848 |
Number of pages | 8 |
Journal | Frontiers in Immunology |
Volume | 9 |
DOIs | |
Publication status | Published - 4 Dec 2018 |
Keywords
- NK cell
- NKG2A
- KIR
- HLA class I
- HLA-E
- multiple myeloma
- immunotherapy
- HLA CLASS-I
- NK CELLS
- MEDIATED LYSIS
- CYTOTOXICITY RECEPTORS
- MISSING SELF
- PHASE-I
- TRANSPLANTATION
- LIGANDS
- POLYMORPHISM
- EXPRESSION