Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization

Keyphrases

• Tumor Necrosis Factor-α 100%
• Myogenic Differentiation 100%
• Protein Destabilization 100%
• MyoD Protein 100%
• MyoD 40%
• Nuclear factor-κB 30%
• Muscle Genes 30%
• Overexpression 20%
• Muscle Wasting 20%
• Skeletal muscle Regeneration 20%
• Cell Cycle Exit 20%
• Mouse Model 10%
• Gene Expression 10%
• RelA 10%
• Transcriptional Activity 10%
• Ubiquitin-proteasome System 10%
• Fibroblasts 10%
• Gene Transcription 10%
• Inhibitory Effect 10%
• Protein Abundance 10%
• Proteolysis 10%
• Protein Stability 10%
• C2C12 Myoblasts 10%
• Nuclear factor-κB Pathway 10%
• Myoblast Cells 10%
• Activation Domain 10%
• Myogenesis 10%
• Muscle Regulatory Factors 10%
• Regulatory Molecules 10%

Biochemistry, Genetics and Molecular Biology

• Tumor Necrosis Factor 100%
• Tumor Necrosis Factor Alpha 100%
• MyoD Protein 100%
• Immunoglobulin Enhancer Binding Protein 40%
• MyoD 40%
• Skeletal Muscle 20%
• Cell Cycle 20%
• Muscle Regeneration 20%
• Protein Catabolism 10%
• Wild Type 10%
• Gene Expression 10%
• Mouse Model 10%
• Ubiquitin 10%
• Fibroblast 10%
• Mediator 10%
• Genetic Transcription 10%
• Transcription 10%
• Proteasome 10%
• C2C12 10%
• Myogenesis 10%
• Transcription Initiation 10%

INIS

• proteins 100%
• tumor necrosis factor 100%
• muscles 90%
• genes 30%
• inhibition 30%
• regeneration 20%
• transcription 20%
• cell cycle 20%
• myoblasts 20%
• mice 10%
• stability 10%
• molecules 10%
• abundance 10%
• mutants 10%
• accumulation 10%
• fibroblasts 10%
• proteolysis 10%