Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Onur Basak, Teresa G. Krieger, Mauro J. Muraro, Kay Wiebrands, Daniel E. Stange, Javier Frias-Aldeguer, Nicolas C. Rivron, Marc van de Wetering, Johan H. van Es, Alexander van Oudenaarden, Benjamin D. Simons, Hans Clevers

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)E610-E619
Number of pages10
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number4
DOIs
Publication statusPublished - 23 Jan 2018

Keywords

  • neural stem cells
  • cellular dynamics
  • modeling
  • single
  • cell sequencing
  • ki67
  • ADULT SUBVENTRICULAR ZONE
  • SELF-RENEWAL
  • VASCULAR NICHE
  • LINEAGE PROGRESSION
  • SUBEPENDYMAL ZONE
  • SONIC HEDGEHOG
  • NEUROGENESIS
  • REVEALS
  • SIGNALS
  • PROTEIN
  • Lateral Ventricles/cytology
  • Cell Proliferation
  • Transcriptome
  • Neurogenesis
  • Receptors, Tumor Necrosis Factor/metabolism
  • Single-Cell Analysis
  • Stem Cell Niche
  • Cell Lineage
  • Animals
  • Mice
  • Neural Stem Cells/physiology

Cite this

Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., Simons, B. D., & Clevers, H. (2018). Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy. Proceedings of the National Academy of Sciences of the United States of America, 115(4), E610-E619. https://doi.org/10.1073/pnas.1715911114