Abstract

Interest in high-sensitivity cardiac troponin I(hs-cTnI) and T(hs-cTnT) has expanded from acute cardiac care to cardiovascular disease(CVD) risk stratification. Whether hs-cTnI and hs-cTnT are interchangeable in the ambulant setting is largely unexplored. Cardiac injury is a mechanism that may underlie the associations between troponin levels and mortality in the general population. In the population-based Maastricht Study, we assessed the correlation and concordance between hs-cTnI and hs-cTnT. Multiple regression analyses were conducted to assess the association of hs-cTnI and hs-cTnT with electrocardiographic (ECG) changes indicative of cardiac abnormalities. In 3016 eligible individuals(mean age, 60 +/- 8 years; 50.6%, men) we found a modest correlation between hs-cTnI and hs-cTnT(r = 0.585). After multiple adjustment, the association with ECG changes indicative of cardiac abnormalities was similar for both hs-cTn assays(OR, hs-cTnI: 1.72,95% CI: 1.40-2.10; OR, hs-cTnT: 1.60,95% CI: 1.22-2.11). The concordance of dichotomized hs-cTnI and hs-cTnT was kappa =0.397 (>= sex-specific 75th percentile). Isolated high levels of hs-cTnI were associated with ECG changes indicative of cardiac abnormalities(OR: 1.93,95% CI: 1.01-3.68), whereas isolated high levels of hs-cTnT were not(OR: 1.07,95% CI: 0.49-2.31). In conclusion, there is a moderate correlation and limited concordance between hs-cTnI and hs-cTnT under non-acute conditions. These data suggest that associations of hs-cTnI and hs-cTnT with cardiac injury detected by ECG are driven by different mechanisms. This information may benefit future development of CVD risk stratification algorithms.

Original languageEnglish
Article number6610
Number of pages9
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 26 Jul 2017

Keywords

  • GLOMERULAR-FILTRATION-RATE
  • HIGHLY SENSITIVE ASSAY
  • CARDIOVASCULAR RISK
  • GENERAL-POPULATION
  • COGNITIVE PERFORMANCE
  • HEALTHY POPULATION
  • PROGNOSTIC VALUE
  • MORTALITY
  • DISEASE
  • COMMUNITY

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