Mucosal biopsy samples from individuals not suspected of having Whipple's disease were tested for the presence of Tropheryma whipplei. A sensitive and specific real-time PCR assay targeting a sequence present seven times in the T. whipplei genome was used. T. whipplei DNA was detected in 2.0 and 3.8% of the patients undergoing gastroduodenoscopy and colonoscopy, respectively, who were tested.
Grasman, M. E., Pettersson, A. M., Catsburg, A., Koek, A. G., van Bodegraven, A. A., & Savelkoul, P. H. M. (2015). Tropheryma whipplei, a Potential Commensal Detected in Individuals Undergoing Routine Colonoscopy. Journal of Clinical Microbiology, 53(12), 3919-3921. https://doi.org/10.1128/JCM.02630-15