Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

Nadeem Sarwar*, Manjinder S. Sandhu, Sally L. Ricketts, Adam S. Butterworth, Emanuele Di Angelantonio, Willem H. Ouwehand, Hugh Watkins, Nilesh J. Samani, Danish Saleheen, Muredach P. Reilly, Aroon D Hingorani, Philippa J. Talmud, John Danesh, Peter S. Braund, Alistair S Hall, J. Thompson, Winfried Marz, Suthesh Sivapalaratnam, Nicole Soranzo, Mieke D. TripDebbie A. Lawlor, Juan P. Casas, S. Ebrahim, B. J. Arsenault, S. Matthijs Boekholdt, Kay-Tee Khaw, Nicholas J. Wareham, Harald Grallert, Thomas Illig, Steve E. Humphries, Daniel J. Rader, J. He, R. Clarke, R. Hamsten, Jemma C. Hopewell, K. Watkins, Philippe Frossard, Panos Deloukas, S. Ye, Julie A. Simpson, A. Onat, E. Komurcu-Bayrak, N. Martinelli, O. Olivieri, D. Girelli, M. Kivimaki, M. Kumari, B.E. Aouizerat, L. Baum, H. Campos, R. Chaaba, B. S. Chen, E. Y. Cho, M. D. Evans, J. Hill, L. A. Hsu, J. A. Hubacek, C. Q. Lai, J. H. Lee, K. Klos, H. Liu, L. Masana, Bela Melegh, Toru Nabika, J. Ribalta, E. Ruiz-Narvaez, G. N. Thomas, B. Tomlinson, C. Szalai, H. Vaverkova, Y. Yamada, Y. Yang, Robert W. Tipping, C. E. Ford, S. L. Pressel, C. M. Ballantyne, A. Brautbar, M. Knuiman, P. H. Winchup, S.G. Wannamethee, Richard W. Morris, S. Kiechl, J. Willeit, P. Santer, A. Mayr, N. Wald, John W G Yarnell, J. Gallacher, Edoardo Casiglia, Valerie Tikhonoff, M. Cushman, Bruce M. Psaty, R. P. Tracy, A. Tybjaerg-Hansen, B. G. Nordestgaard, M. Benn, R. Frikke-Schmidt, S. Giampaoli, L. Palmieri, S. Panico, D. Vanuzzo, L. Pilotto, Agustin Gomez-de-la-Camara, J. A. Gomez-Gerique, Laura Simons, J. McCallum, Yechiel Friedlander, F. Gerry R. Fowkes, John A. Lee, Clare J. Taylor, Jack M Guralnik, Caroline L. Phillips, W. R. Wallace, Dan G. Blazer, H. Brenner, E. Raum, Heiko Mueller, Dietrich Rothenbacher, J-H Jansson, Patrik Wennberg, A. Nissinen, C. Donfrancesco, Veikko Salomaa, K. Harald, M. J. Pencina, E. Vartiainen, Ralph B., Sr. D'Agostino, Ramachandran S. Vasan, E.M. Bladbjerg, T. Jorgensen, L. Moller, J. Jespersen, Rachel Dankner, A. Chetrit, F. Lubin, C. Bjoerkelund, L. Lissner, C. Bengtsson, Peter Cremer, Dorothea Nagel, Beatriz Rodriguez, Jacqueline M. Dekker, G. Nijpels, C. D. A. Stehouwer, H. Iso, A. Kitamura, H. Noda, Jukka T. Salonen, K. Nyssoenen, T.-P. Tuimainen, S. Voutilainen, Tom W. Meade, Jackie A. Cooper, Lewis H. Kuller, G. Grandits, Richard F. Gillum, Michael Mussolino, E. Rimm, S.E. Hankinson, J. A. E. Manson, J. K. Pai, K. A. Bauer, S. Sato, Y. Naito, Philippe Amouyel, D. Arveiler, A C. Evans, Jean Ferrieres, H. Schulte-Nölke, G. Assmann, Chris J. Packard, N. Sattar, Rudi G. J. Westendorp, Brendan M Buckley, B. Cantin, B. Lamarche, J. -P. Despres, Gilles R. Dagenais, Elizabeth Barrett-Connor, D. L. Wingard, R. R. Bettencourt, V. Gudnason, T. Aspelund, G. Sigurdsson, B. Thorsson, Maurizio Trevisan, Hugh Tunstall-Pedoe, R. Tavendale, Gordon D. O. Lowe, M. Woodward, Barbara V. Howard, Y. Zhang, L. Best, Jason G. Umans, Y. Ben-Shlomo, G. Davey-Smith, Inger Njolstad, Ellisiv B. Mathiesen, M. L. Lochen, Tom Wilsgaard, E. Ingelsson, I. Lind, V. Giedraitis, K. Michaeelsson, Eric J. Brunner, M. Shipley, Paul M. Ridker, J.E. Buring, J. Shepherd, S.M. Cobbe, I. Ford, M. Robertson, A. Marin Ibanez, E. J. M. Feskens, D. Kromhout, M. Walker, Stanley J. Watson, R. Collins, S. Kaptoge, P. L. Perry, A. Thompson, S. G. Thompson, Ian R. White, Angela M. Wood

*Corresponding author for this work

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Abstract

Background whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality.
Original languageEnglish
Pages (from-to)1634-1639
JournalLancet
Volume375
Issue number9726
DOIs
Publication statusPublished - 8 May 2010

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