Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi*, Abhishek D. Garg*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

91 Citations (Web of Science)

Abstract

The term 'immunogenic cell death' (ICD) denotes an immunologically unique type of regulated cell death that enables, rather than suppresses, T cell-driven immune responses that are specific for antigens derived from the dying cells. The ability of ICD to elicit adaptive immunity heavily relies on the immunogenicity of dying cells, implying that such cells must encode and present antigens not covered by central tolerance (antigenicity), and deliver immunostimulatory molecules such as damage-associated molecular patterns and cytokines (adjuvanticity). Moreover, the host immune system must be equipped to detect the antigenicity and adjuvanticity of dying cells. As cancer (but not normal) cells express several antigens not covered by central tolerance, they can be driven into ICD by some therapeutic agents, including (but not limited to) chemotherapeutics of the anthracycline family, oxaliplatin and bortezomib, as well as radiation therapy. In this Trial Watch, we describe current trends in the preclinical and clinical development of ICD-eliciting chemotherapy as partner for immunotherapy, with a focus on trials assessing efficacy in the context of immunomonitoring.

Original languageEnglish
Article number1703449
Number of pages23
JournalOncoImmunology
Volume9
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • Antigen-presenting cell
  • autophagy
  • cytotoxic T lymphocyte
  • endoplasmic reticulum stress
  • CAR T cells
  • cytokines
  • chemokines
  • dendritic cell
  • immune checkpoint blocker
  • type I interferon
  • CD8(+) T-CELLS
  • RANDOMIZED PHASE-2 TRIAL
  • BREAST-CANCER PATIENTS
  • SOFT-TISSUE SARCOMA
  • FIND-ME SIGNAL
  • DENDRITIC CELLS
  • CHECKPOINT BLOCKADE
  • APOPTOTIC CELLS
  • CALRETICULIN EXPOSURE
  • ANTITUMOR IMMUNITY

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