Trends in the Incidence of Bowen Disease Based on a Single-Center Study in the Netherlands

Maud H. E. Jansen*, Hilal Ozhan-Hasan, Patty J. Nelemans, Veronique J. Winnepenninckx, Klara Mosterd

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

BACKGROUND Incidence trends of nonmelanoma skin cancer show an increase. Few data have been published about the incidence of Bowen disease (BD). Three previous studies, conducted more than 15 years ago in North America, found large variation in incidence rates in Caucasians, and trends over longer periods have never been studied.

OBJECTIVE To estimate the incidence of BD in a Caucasian population in Northern Europe (Maastricht, the Netherlands) between 2003 and 2013.

METHODS Primary and histologically confirmed BD, diagnosed in Maastricht, the Netherlands, in the years 2003, 2008, and 2013, was retrieved from a pathology database. Age-standardized and sex-specific incidence rates per 100,000 inhabitants were calculated by using the age distribution of the European standard population of 2013.

RESULTS A statistically significant increase in the annual age-standardized incidence rates per 100,000 people was found from 8.1 (95% confidence interval [CI] 3.7-12.5) in 2003 to 68.9 (95% CI 57.2-80.7) in 2013 (p <.001). For women, there was an increase from 7.7/100,000 (95% CI 2.0-13.4) in 2003 to 76.8/100,000 (95% CI 60.2-93.5) in 2013, respectively (p <.001). An increase from 8.8/100,000 (95% CI 1.8-15.9) in 2003 to 59.2/100,000 men (95% CI 42.8-75.6) in 2013 (p <.001) was found.

CONCLUSION These findings suggest an increase in the annual age-standardized incidence rates in BD.

Original languageEnglish
Pages (from-to)1353-1358
Number of pages6
JournalDermatologic Surgery
Volume45
Issue number11
DOIs
Publication statusPublished - Nov 2019

Keywords

  • SQUAMOUS-CELL CARCINOMA
  • RISK

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