Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021

Hidde Swartjes; Femke P C Sijtsma; Marloes A G Elferink; Felice N van Erning; Leon M G Moons; Henk M W Verheul; Maaike Berbée; Pauline A J Vissers; Johannes H W de Wilt

doi:10.1016/j.ejca.2024.114104

Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021

Hidde Swartjes^*, Femke P C Sijtsma^*, Marloes A G Elferink, Felice N van Erning, Leon M G Moons, Henk M W Verheul, Maaike Berbée, Pauline A J Vissers, Johannes H W de Wilt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The epidemiology of colorectal cancer (CRC) has changed rapidly over the years. The aim of this study was to assess the trends in incidence, treatment, and relative survival (RS) of patients diagnosed with CRC in the Netherlands between 2000 and 2021. PATIENTS AND METHODS: 2 75667 patients diagnosed with CRC between 2000 and 2021 were included from the Netherlands Cancer Registry. Analyses were stratified for disease extent (localised: T1-3N0M0; regional: T4N0M0/T1-4N1-2M0; distant: T1-4N0-2M1) and localisation (colon; rectum). Trends were assessed with joinpoint regression. RESULTS: CRC incidence increased until the mid-2010s but decreased strongly thereafter to rates comparable with the early 2000s. Amongst other trend changes, local excision rates increased for patients with localised colon (2021: 13.6 %) and rectal cancer (2021: 34.9 %). Moreover, primary tumour resection became less common in patients with distant colon (2000-2021: 60.9-12.5 %) or rectal cancer (2000-2021: 47.8-6.9 %), while local treatment of metastases rates increased. Five-year RS improved continuously for localised and regional colon (97.7 % and 72.0 % in 2017, respectively) and rectal cancer (95.2 % and 76.3 % in 2017, respectively). The rate of anti-cancer treatments decreased in distant colon (2010-2021: 80.3 % to 67.2 %; p < 0.001) and rectal cancer (2011-2021: 86.0 % to 77.0 %; p < 0.001). The improvement of five-year RS stagnated for distant colon (2010-2017: 11.2 % to 11.9 %; average percentage of change [APC]: 2.1, 95 % confidence interval [CI]: -7.6, 4.7) and rectal cancer (2009-2017: 12.7 % to 15.6 %; APC: 1.4, 95 % CI: -19.1, 5.5). CONCLUSIONS: Major changes in the incidence and treatment of CRC between 2000 and 2021 were identified and quantified. Five-year RS increased continuously for patients with localised and regional CRC, but stagnated for patients with distant CRC, likely caused by decreased rates of anti-cancer treatment in this group.

Original language	English
Article number	114104
Number of pages	8
Journal	European Journal of Cancer
Volume	205
Early online date	7 May 2024
DOIs	https://doi.org/10.1016/j.ejca.2024.114104
Publication status	Published - Jul 2024

Keywords

Colorectal neoplasms
Epidemiology*
Incidence
Survival analysis
Therapy*

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10.1016/j.ejca.2024.114104

1 Erratum / corrigendum / retractions

Corrigendum to "Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021" Volume 205, July 2024, 114104
Swartjes, H., Sijtsma, F. P. C., Elferink, M. A. G., van Erning, F. N., Moons, L. M. G., Verheul, H. M. W., Berbée, M., Vissers, P. A. J. & de Wilt, J. H. W., Aug 2024, In: European Journal of Cancer. 207, 2 p., 114155.
Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

Cite this

Swartjes, H., Sijtsma, F. P. C., Elferink, M. A. G., van Erning, F. N., Moons, L. M. G., Verheul, H. M. W., Berbée, M., Vissers, P. A. J., & de Wilt, J. H. W. (2024). Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021. European Journal of Cancer, 205, Article 114104. https://doi.org/10.1016/j.ejca.2024.114104

@article{1f1c3973ddb347fc87838da983f58859,

title = "Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021",

abstract = "BACKGROUND: The epidemiology of colorectal cancer (CRC) has changed rapidly over the years. The aim of this study was to assess the trends in incidence, treatment, and relative survival (RS) of patients diagnosed with CRC in the Netherlands between 2000 and 2021. PATIENTS AND METHODS: 2 75667 patients diagnosed with CRC between 2000 and 2021 were included from the Netherlands Cancer Registry. Analyses were stratified for disease extent (localised: T1-3N0M0; regional: T4N0M0/T1-4N1-2M0; distant: T1-4N0-2M1) and localisation (colon; rectum). Trends were assessed with joinpoint regression. RESULTS: CRC incidence increased until the mid-2010s but decreased strongly thereafter to rates comparable with the early 2000s. Amongst other trend changes, local excision rates increased for patients with localised colon (2021: 13.6 %) and rectal cancer (2021: 34.9 %). Moreover, primary tumour resection became less common in patients with distant colon (2000-2021: 60.9-12.5 %) or rectal cancer (2000-2021: 47.8-6.9 %), while local treatment of metastases rates increased. Five-year RS improved continuously for localised and regional colon (97.7 % and 72.0 % in 2017, respectively) and rectal cancer (95.2 % and 76.3 % in 2017, respectively). The rate of anti-cancer treatments decreased in distant colon (2010-2021: 80.3 % to 67.2 %; p < 0.001) and rectal cancer (2011-2021: 86.0 % to 77.0 %; p < 0.001). The improvement of five-year RS stagnated for distant colon (2010-2017: 11.2 % to 11.9 %; average percentage of change [APC]: 2.1, 95 % confidence interval [CI]: -7.6, 4.7) and rectal cancer (2009-2017: 12.7 % to 15.6 %; APC: 1.4, 95 % CI: -19.1, 5.5). CONCLUSIONS: Major changes in the incidence and treatment of CRC between 2000 and 2021 were identified and quantified. Five-year RS increased continuously for patients with localised and regional CRC, but stagnated for patients with distant CRC, likely caused by decreased rates of anti-cancer treatment in this group.",

keywords = "Colorectal neoplasms, Epidemiology*, Incidence, Survival analysis, Therapy*",

author = "Hidde Swartjes and Sijtsma, {Femke P C} and Elferink, {Marloes A G} and {van Erning}, {Felice N} and Moons, {Leon M G} and Verheul, {Henk M W} and Maaike Berb{\'e}e and Vissers, {Pauline A J} and {de Wilt}, {Johannes H W}",

year = "2024",

month = jul,

doi = "10.1016/j.ejca.2024.114104",

language = "English",

volume = "205",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "ELSEVIER SCI LTD",

}

TY - JOUR

T1 - Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021

AU - Swartjes, Hidde

AU - Sijtsma, Femke P C

AU - Elferink, Marloes A G

AU - van Erning, Felice N

AU - Moons, Leon M G

AU - Verheul, Henk M W

AU - Berbée, Maaike

AU - Vissers, Pauline A J

AU - de Wilt, Johannes H W

PY - 2024/7

Y1 - 2024/7

N2 - BACKGROUND: The epidemiology of colorectal cancer (CRC) has changed rapidly over the years. The aim of this study was to assess the trends in incidence, treatment, and relative survival (RS) of patients diagnosed with CRC in the Netherlands between 2000 and 2021. PATIENTS AND METHODS: 2 75667 patients diagnosed with CRC between 2000 and 2021 were included from the Netherlands Cancer Registry. Analyses were stratified for disease extent (localised: T1-3N0M0; regional: T4N0M0/T1-4N1-2M0; distant: T1-4N0-2M1) and localisation (colon; rectum). Trends were assessed with joinpoint regression. RESULTS: CRC incidence increased until the mid-2010s but decreased strongly thereafter to rates comparable with the early 2000s. Amongst other trend changes, local excision rates increased for patients with localised colon (2021: 13.6 %) and rectal cancer (2021: 34.9 %). Moreover, primary tumour resection became less common in patients with distant colon (2000-2021: 60.9-12.5 %) or rectal cancer (2000-2021: 47.8-6.9 %), while local treatment of metastases rates increased. Five-year RS improved continuously for localised and regional colon (97.7 % and 72.0 % in 2017, respectively) and rectal cancer (95.2 % and 76.3 % in 2017, respectively). The rate of anti-cancer treatments decreased in distant colon (2010-2021: 80.3 % to 67.2 %; p < 0.001) and rectal cancer (2011-2021: 86.0 % to 77.0 %; p < 0.001). The improvement of five-year RS stagnated for distant colon (2010-2017: 11.2 % to 11.9 %; average percentage of change [APC]: 2.1, 95 % confidence interval [CI]: -7.6, 4.7) and rectal cancer (2009-2017: 12.7 % to 15.6 %; APC: 1.4, 95 % CI: -19.1, 5.5). CONCLUSIONS: Major changes in the incidence and treatment of CRC between 2000 and 2021 were identified and quantified. Five-year RS increased continuously for patients with localised and regional CRC, but stagnated for patients with distant CRC, likely caused by decreased rates of anti-cancer treatment in this group.

AB - BACKGROUND: The epidemiology of colorectal cancer (CRC) has changed rapidly over the years. The aim of this study was to assess the trends in incidence, treatment, and relative survival (RS) of patients diagnosed with CRC in the Netherlands between 2000 and 2021. PATIENTS AND METHODS: 2 75667 patients diagnosed with CRC between 2000 and 2021 were included from the Netherlands Cancer Registry. Analyses were stratified for disease extent (localised: T1-3N0M0; regional: T4N0M0/T1-4N1-2M0; distant: T1-4N0-2M1) and localisation (colon; rectum). Trends were assessed with joinpoint regression. RESULTS: CRC incidence increased until the mid-2010s but decreased strongly thereafter to rates comparable with the early 2000s. Amongst other trend changes, local excision rates increased for patients with localised colon (2021: 13.6 %) and rectal cancer (2021: 34.9 %). Moreover, primary tumour resection became less common in patients with distant colon (2000-2021: 60.9-12.5 %) or rectal cancer (2000-2021: 47.8-6.9 %), while local treatment of metastases rates increased. Five-year RS improved continuously for localised and regional colon (97.7 % and 72.0 % in 2017, respectively) and rectal cancer (95.2 % and 76.3 % in 2017, respectively). The rate of anti-cancer treatments decreased in distant colon (2010-2021: 80.3 % to 67.2 %; p < 0.001) and rectal cancer (2011-2021: 86.0 % to 77.0 %; p < 0.001). The improvement of five-year RS stagnated for distant colon (2010-2017: 11.2 % to 11.9 %; average percentage of change [APC]: 2.1, 95 % confidence interval [CI]: -7.6, 4.7) and rectal cancer (2009-2017: 12.7 % to 15.6 %; APC: 1.4, 95 % CI: -19.1, 5.5). CONCLUSIONS: Major changes in the incidence and treatment of CRC between 2000 and 2021 were identified and quantified. Five-year RS increased continuously for patients with localised and regional CRC, but stagnated for patients with distant CRC, likely caused by decreased rates of anti-cancer treatment in this group.

KW - Colorectal neoplasms

KW - Epidemiology

KW - Incidence

KW - Survival analysis

KW - Therapy

U2 - 10.1016/j.ejca.2024.114104

DO - 10.1016/j.ejca.2024.114104

M3 - Article

SN - 0959-8049

VL - 205

JO - European Journal of Cancer

JF - European Journal of Cancer

M1 - 114104

ER -

Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021

Abstract

Keywords

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Research output

Corrigendum to "Trends in incidence, treatment, and relative survival of colorectal cancer in the Netherlands between 2000 and 2021" Volume 205, July 2024, 114104

Cite this