Trends in Antibiotic Prescribing in Adults in Dutch General Practice

Michiel B. Haeseker*, Nicole H.T.M. Dukers-Muijrers, Christian J. P. A. Hoebe, Cathrien A. Bruggeman, Jochen W. L. Cals, Annelies Verbon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Antibiotic consumption is associated with adverse drug events (ADE) and increasing antibiotic resistance. Detailed information of antibiotic prescribing in different age categories is scarce, but necessary to develop strategies for prudent antibiotic use. The aim of this study was to determine the antibiotic prescriptions of different antibiotic classes in general practice in relation to age. Methodology: Retrospective study of 22 rural and urban general practices from the Dutch Registration Network Family Practices (RNH). Antibiotic prescribing data were extracted from the RNH database from 2000-2009. Trends over time in antibiotic prescriptions were assessed with multivariate logistic regression including interaction terms with age. Registered ADEs as a result of antibiotic prescriptions were also analyzed. Principal Findings: In total 658,940 patients years were analyzed. In 11.5% (n = 75,796) of the patient years at least one antibiotic was prescribed. Antibiotic prescriptions increased for all age categories during 2000-2009, but the increase in elderly patients (>80 years) was most prominent. In 2000 9% of the patients >80 years was prescribed at least one antibiotic to 22% in 2009 (P
Original languageEnglish
Article numbere51860
Issue number12
Publication statusPublished - 12 Dec 2012


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