Treatment with a GPIIb/IIIa antagonist inhibits thrombin generation in platelet rich plasma from patients

I. M. L. W. Keularts; S. Beguin; C. de Zwaan; H. C. Hemker

doi:10.1055/s-0037-1615213

Treatment with a GPIIb/IIIa antagonist inhibits thrombin generation in platelet rich plasma from patients

I. M. L. W. Keularts, S. Beguin, C. de Zwaan, H. C. Hemker^*

^*Corresponding author for this work

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Abstract

Infusion of the GPIIb/IIIa-inhibitor MK383 inhibits thrombin generation in platelet rich plasma by interfering with the production of platelet procoagulant phospholipid exposure. The effect is similar to that of 0.2 U/ml of heparin. Heparin infusion, well known to inhibit thrombin generation by fostering antithrombin activity: inhibits the formation of platelet-derived procoagulant microparticles, probably by decreasing the formation of free thrombin, which, under our circumstances, is the main platelet activator.

Original language	English
Pages (from-to)	370-371
Number of pages	2
Journal	Thrombosis and Haemostasis
Volume	80
Issue number	3
DOIs	https://doi.org/10.1055/s-0037-1615213
Publication status	Published - 1 Jan 1998

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abstract = "Infusion of the GPIIb/IIIa-inhibitor MK383 inhibits thrombin generation in platelet rich plasma by interfering with the production of platelet procoagulant phospholipid exposure. The effect is similar to that of 0.2 U/ml of heparin. Heparin infusion, well known to inhibit thrombin generation by fostering antithrombin activity: inhibits the formation of platelet-derived procoagulant microparticles, probably by decreasing the formation of free thrombin, which, under our circumstances, is the main platelet activator.",

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