TY - JOUR
T1 - Treatment of upper-extremity outflow thrombosis
AU - van den Houten, Marijn M. L.
AU - van Grinsven, Regine
AU - Pouwels, Sjaak
AU - Yo, Lonneke S. F.
AU - van Sambeek, Marc R. H. M.
AU - Teijink, Joep A. W.
PY - 2016/3
Y1 - 2016/3
N2 - Approximately 10% of all cases of deep vein thrombosis (DVT) occur in the upper extremities. The most common secondary cause of upper-extremity DVT (UEDVT) is the presence of a venous catheter. Primary UEDVT is far less common and usually occurs in patients with anatomic abnormalities of the costoclavicular space causing compression of the subclavian vein, called venous thoracic outlet syndrome (VTOS). Subsequently, movement of the arm results in repetitive microtrauma to the vein and its surrounding structures causing apparent spontaneous' thrombosis, or Paget-Schrotter syndrome. Treatment of UEDVT aims at elimination of the thrombus, thereby relieving acute symptoms, and preventing recurrence. Initial management for all UEDVT patients consists of anticoagulant therapy. In patients with Paget-Schrotter syndrome the underlying VTOS necessitates a more aggressive management strategy. Several therapeutic options exist, including catheter-directed thrombolysis, surgical decompression through first rib resection, and percutaneous transluminal angioplasty of the vein. However, several controversies exist regarding their indication and timing.
AB - Approximately 10% of all cases of deep vein thrombosis (DVT) occur in the upper extremities. The most common secondary cause of upper-extremity DVT (UEDVT) is the presence of a venous catheter. Primary UEDVT is far less common and usually occurs in patients with anatomic abnormalities of the costoclavicular space causing compression of the subclavian vein, called venous thoracic outlet syndrome (VTOS). Subsequently, movement of the arm results in repetitive microtrauma to the vein and its surrounding structures causing apparent spontaneous' thrombosis, or Paget-Schrotter syndrome. Treatment of UEDVT aims at elimination of the thrombus, thereby relieving acute symptoms, and preventing recurrence. Initial management for all UEDVT patients consists of anticoagulant therapy. In patients with Paget-Schrotter syndrome the underlying VTOS necessitates a more aggressive management strategy. Several therapeutic options exist, including catheter-directed thrombolysis, surgical decompression through first rib resection, and percutaneous transluminal angioplasty of the vein. However, several controversies exist regarding their indication and timing.
KW - Paget-Schrotter
KW - effort thrombosis
KW - deep venous thrombosis
U2 - 10.1177/0268355516632661
DO - 10.1177/0268355516632661
M3 - Article
C2 - 26916766
SN - 0268-3555
VL - 31
SP - 28
EP - 33
JO - Phlebology: The Journal of Venous Disease
JF - Phlebology: The Journal of Venous Disease
ER -