Treatment and survival of rectal cancer patients over the age of 80 years: a EURECCA international comparison

Yvette H. M. Claassen, Nina C. A. Vermeer, Lene H. Iversen, Elizabeth van Eycken, Marianne G. Guren, Pawel Mroczkowski, Anna Martling, Antonio Cazador, Robert Johansson, Tamara Vandendael, Arne Wibe, Bjorn Moller, Hans Lippert, Harm J. T. Rutten, Johanneke E. A. Portielje, Gerrit J. Liefers, Fabian A. Holman, Cornelis J. H. van de Velde, Esther Bastiaannet*

*Corresponding author for this work

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Abstract

BACKGROUND: The optimal treatment strategy for older rectal cancer patients remains unclear. The current study aimed to compare treatment and survival of rectal cancer patients aged 80+. METHODS: Patients of >= 80 years diagnosed with rectal cancer between 2001 and 2010 were included. Population-based cohorts from Belgium (BE), Denmark (DK), the Netherlands (NL), Norway (NO) and Sweden (SE) were compared side by side for neighbouring countries on treatment strategy and 5-year relative survival (RS), adjusted for sex and age. Analyses were performed separately for stage I-III patients and stage IV patients. RESULTS: Overall, 19 634 rectal cancer patients were included. For stage I-III patients, 5-year RS varied from 61.7% in BE to 72.3% in SE. Proportion of preoperative radiotherapy ranged between 7.9% in NO and 28.9% in SE. For stage IV patients, 5-year RS differed from 2.8% in NL to 5.6% in BE. Rate of patients undergoing surgery varied from 22.2% in DK to 40.8% in NO. CONCLUSIONS: Substantial variation was observed in the 5-year relative survival between European countries for rectal cancer patients aged 80+, next to a wide variation in treatment, especially in the use of preoperative radiotherapy in stage I-III patients and in the rate of patients undergoing surgery in stage IV patients.
Original languageEnglish
Pages (from-to)517-522
Number of pages6
JournalBritish Journal of Cancer
Volume119
Issue number4
DOIs
Publication statusPublished - 14 Aug 2018

Keywords

  • IV COLORECTAL-CANCER
  • ELDERLY-PATIENTS
  • PREOPERATIVE RADIOTHERAPY
  • DELAYED SURGERY
  • OLDER PATIENTS
  • PRIMARY TUMOR
  • FOLLOW-UP
  • COUNTRIES
  • RESECTION
  • CHEMORADIOTHERAPY

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