Treatment adherence therapy in people with psychotic disorders: randomised controlled trial

A. B. P. Staring*, Mark van der Gaag, G. T. Koopmans, J. P. Selten, Nico J. M. van Beveren, M. W. Hengeveld, A. J. M. Loonen, C. L. Mulder

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence.To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly.Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159).Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve.Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission.
Original languageEnglish
Pages (from-to)448-455
JournalBritish Journal of Psychiatry
Issue number6
Publication statusPublished - Dec 2010

Cite this